高级富血小板纤维蛋白(A- prf)和富生长因子血浆(PRGF)在上颌窦增强术中的骨再生:一项随机对照试验

IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Panagiotis Dragonas, Hari S Prasad, Qingzhao Yu, Elizabeth T Mayer, Paul L Fidel
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引用次数: 2

摘要

本随机对照试验的目的是分析和比较晚期富血小板纤维蛋白(A-PRF)和富生长因子血浆(PRGF)联合去蛋白牛骨矿物质(DBBM)对上颌窦增强术(MSA)骨再生结果的影响。连续招募15例需要MSA的患者。分别采用DBBM单独(对照组)、DBBM与A-PRF混合(PRF组)、DBBM与PRGF混合(PRGF组)进行上颌窦移植。在6个月的愈合期后,在植入植体之前收集骨芯活检样本进行组织学和组织形态学分析。对照组矿化组织(MT)平均百分比为20.33±11.50,PRF组为32.20±7.29,PRGF组为34.80±6.83,三组间差异无统计学意义(P > 0.05)。对照组(24.00±7.94)、PRF组(26.00±7.78)、PRGF组(15.80±8.23)的平均残余植骨材料百分率(RBGM),三组间差异无统计学意义(P > 0.05)。对照组、PRF组和PRGF组非矿化组织(NMT)的平均百分比分别为55.66±7.77、41.40±8.32和49.60±5.68,三组间差异无统计学意义(P > 0.05)。这些发现表明,在DBBM中添加A-PRF和PRGF并不能提高上颌窦增强术中新骨形成的结果。在评估的任何变量中,两种血小板浓缩物都不优于另一种。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bone Regeneration in Maxillary Sinus Augmentation Using Advanced Platelet-Rich Fibrin (A-PRF) and Plasma Rich in Growth Factors (PRGF): A Pilot Randomized Controlled Trial

The purpose of this pilot randomized controlled trial was to analyze and compare the effects of advanced platelet-rich fibrin (A-PRF) and plasma rich in growth factors (PRGF) combined with deproteinized bovine bone mineral (DBBM) on bone regeneration outcomes in maxillary sinus augmentation (MSA) procedures. A total of 15 patients in need of MSA were consecutively recruited. Maxillary sinuses were grafted with DBBM alone (control group), DBBM mixed with A-PRF (PRF group), or DBBM mixed with PRGF (PRGF group). After a 6-month healing period, bone core biopsy samples were collected prior to implant placement for histologic and histomorphometric analyses. The mean percentage of mineralized tissue (MT) was 20.33 ± 11.50 in the control group, 32.20 ± 7.29 for the PRF group, and 34.80 ± 6.83 for the PRGF group, with no statistically significant differences across the three groups (P > .05). The mean percentage of remaining bone grafting material (RBGM) was 24.00 ± 7.94 for the control group, 26.00 ± 7.78 for the PRF group, and 15.80 ± 8.23 for the PRGF group, with no statistically significant differences across the three groups (P > .05). Finally, the mean percentage of nonmineralized tissue (NMT) was 55.66 ± 7.77 for the control group, 41.40 ± 8.32 for the PRF group, and 49.60 ± 5.68 for the PRGF group, with no statistically signifcant differences across the three groups (P > .05). These findings suggest that the addition of A-PRF and PRGF to DBBM does not enhance new bone formation outcomes in maxillary sinus augmentation procedures. Neither of the two platelet concentrates were superior to the other in any of the variables assessed.

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来源期刊
CiteScore
2.90
自引率
6.20%
发文量
113
审稿时长
6-12 weeks
期刊介绍: The International Journal of Periodontics & Restorative Dentistry will publish manuscripts concerned with all aspects of clinical periodontology, restorative dentistry, and implantology. This includes pertinent research as well as clinical methodology (their interdependence and relationship should be addressed where applicable); proceedings of relevant symposia or conferences; and quality review papers. Original manuscripts are considered for publication on the condition that they have not been published or submitted for publication elsewhere.
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