停用大麻后炎症标志物的增加及其与精神病症状的关系。

IF 3.8 4区 医学 Q1 Medicine
Acta Neuropsychiatrica Pub Date : 2024-04-01 Epub Date: 2023-04-28 DOI:10.1017/neu.2023.24
Bruno Romeo, Valentine Lestra, Catherine Martelli, Ammar Amirouche, Amine Benyamina, Nora Hamdani
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引用次数: 0

摘要

简介精神病患者免疫系统失衡的问题已得到广泛研究。然而,尽管精神病患者吸食大麻(四氢大麻酚)的比例较高,但很少有研究调查吸食大麻对炎症指标的影响:这项回顾性研究纳入了 102 名住院患者。测量了白细胞公式、hsCRP、纤维蛋白原水平和尿液中的四氢大麻酚,并对使用大麻者(四氢大麻酚+)和不使用大麻者(四氢大麻酚-)在基线和停止使用大麻 4 周后的情况进行了比较:停用大麻后,我们发现与 THC- 组相比,THC+ 组的白细胞水平(p < 0.01)和单核细胞水平(p = 0.05)在基线和 4 周后有更高的升高,淋巴细胞水平(p = 0.06)也有最高升高的统计趋势。在 4 周时,发现 THC+ 组的白细胞(p = 0.03)、淋巴细胞(p = 0.04)和单核细胞(p < 0.01)计数最高,而基线时没有发现差异。研究发现,4 周时的单核细胞计数与基线阳性和阴性综合征量表(PANSS)阴性子分数(p = 0.045)呈正相关,基线和 4 周时的单核细胞计数变化与 4 周时的 PANSS 总分(p = 0.05)呈正相关:结论:戒除 THC 与炎症标志物(包括白细胞、淋巴细胞和单核细胞水平)的增加有关,这与精神病患者的症状相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increased markers of inflammation after cannabis cessation and their association with psychotic symptoms.

Introduction: A dysbalance of the immune system in psychotic disorders has been well investigated. However, despite a higher prevalence of cannabis (THC) consumption in patients with psychosis, few studies have investigated the impact of this use on inflammatory markers.

Methods: One hundred and two inpatients were included in this retrospective study. Leukocytic formula, hsCRP, fibrinogen levels and urinary THC were measured, and comparisons were performed at baseline and after 4 weeks of cannabis cessation between cannabis users (THC+) and non-users (THC-).

Results: After cannabis cessation, we found a greater increase in leucocyte level (p < 0.01), monocyte level (p = 0.05) and a statistical trend to a highest increase of lymphocyte level (p = 0.06) between baseline and 4 weeks in the THC+ group as compared to the THC- group. At 4 weeks, highest leucocyte (p = 0.03), lymphocyte (p = 0.04) and monocyte (p < 0.01) counts were found in the THC+ group, whereas at baseline no difference was found. A positive correlation was found between monocyte count at 4 weeks and baseline Positive and Negative Syndrome Scale (PANSS) negative subscore (p = 0.045) and between the variation of monocyte count between baseline and 4 weeks and the PANSS total score at 4 weeks (p = 0.05).

Conclusion: THC cessation is associated with an increase in inflammatory markers, including white blood cell, lymphocyte and monocyte levels, which correlates with symptomatology of patients with psychosis.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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