来自NSP7的肽能够形成淀粉样蛋白样原纤维:人工产物还是对药物设计的挑战?

IF 2.5 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Proteins and proteomics Pub Date : 2023-02-01 DOI:10.1016/j.bbapap.2022.140884

Yuri Garmay , Aleksandr Rubel , Vladimir Egorov

引用次数: 1

摘要

•我们在NSP7 SARS-CoV2蛋白中发现了潜在的淀粉样蛋白片段•NSP7(52-62)片段能够形成淀粉样原纤维•讨论了使用这种肽作为抗病毒药物基础的可能性

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Peptide from NSP7 is able to form amyloid-like fibrils: Artifact or challenge to drug design?

查看原文本刊更多论文

Peptide from NSP7 is able to form amyloid-like fibrils: Artifact or challenge to drug design?

•
We found potential amyloidogenic fragment in NSP7 SARS-CoV2 protein in silico
•
NSP7 (52–62) fragment is able to form amyloid-like fibrils
•
The possibility of using such a peptide as the basis for an antiviral drug is discussed

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来源期刊

Biochimica et biophysica acta. Proteins and proteomics 生物-生化与分子生物学

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

33 days

期刊介绍： BBA Proteins and Proteomics covers protein structure conformation and dynamics; protein folding; protein-ligand interactions; enzyme mechanisms, models and kinetics; protein physical properties and spectroscopy; and proteomics and bioinformatics analyses of protein structure, protein function, or protein regulation.