{"title":"来自NSP7的肽能够形成淀粉样蛋白样原纤维:人工产物还是对药物设计的挑战?","authors":"Yuri Garmay , Aleksandr Rubel , Vladimir Egorov","doi":"10.1016/j.bbapap.2022.140884","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>•</span><span><p>We found potential amyloidogenic fragment in NSP7 SARS-CoV2 protein <em>in silico</em></p></span></li><li><span>•</span><span><p>NSP7 (52–62) fragment is able to form amyloid-like fibrils</p></span></li><li><span>•</span><span><p>The possibility of using such a peptide as the basis for an antiviral drug is discussed</p></span></li></ul></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711895/pdf/","citationCount":"1","resultStr":"{\"title\":\"Peptide from NSP7 is able to form amyloid-like fibrils: Artifact or challenge to drug design?\",\"authors\":\"Yuri Garmay , Aleksandr Rubel , Vladimir Egorov\",\"doi\":\"10.1016/j.bbapap.2022.140884\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>•</span><span><p>We found potential amyloidogenic fragment in NSP7 SARS-CoV2 protein <em>in silico</em></p></span></li><li><span>•</span><span><p>NSP7 (52–62) fragment is able to form amyloid-like fibrils</p></span></li><li><span>•</span><span><p>The possibility of using such a peptide as the basis for an antiviral drug is discussed</p></span></li></ul></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711895/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1570963922001315\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1570963922001315","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
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