甲状腺乳头状癌细针穿刺细胞形态特征的准确解释及临床意义。

IF 2.6 4区 医学 Q3 CELL BIOLOGY
Xue-Jiao Xiong, Ming-Ming Xiao, Yi-Xia Zhang, Dong-Ge Liu, Mu-Lan Jin, Jian Wang, Hong-Tao Xu, Qing-Chang Li, Guang-Ping Wu
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引用次数: 0

摘要

甲状腺乳头状癌(PTC)是甲状腺最常见的恶性肿瘤;细针吸细胞学检查是PTC术前最基本、最可靠的诊断方法。然而,目前尚不清楚哪种细胞形态学改变可以作为诊断PTC的可靠标准。对337例经术后组织学证实的PTC患者进行回顾性分析。另外197名随机选择的甲状腺良性病变患者被纳入研究并作为对照组。真乳头状排列、旋流排列和逃逸排列的特异性都很高,均为100%,但只有旋流排列具有理想的敏感性(77.61%)。核体积特征具有90%以上的高灵敏度,但核拥挤和核重叠的特异性均过低,仅为16.34%和23.35%。5种核结构特征的敏感性均在90%以上,但只有核内胞质假包涵体(INCIs)特异性达到100%,核轮廓不规则、核色苍白、染色质粉末状也具有理想的解释价值,除了沟槽和边缘放置的微核仁。虽然沙砾小体(PBs)的敏感性较低,但特异性为100%。在制备方法方面,液体基制备法(LBP)明显优于常规涂片法。平行试验联合检测方法的诊断效率显示,在不降低特异性的情况下,敏感性随着形态特征数量的增加而增加,最终达到98.81%。inci和漩涡排列是诊断PTC最常见和最重要的指标,而乳头状排列、核的拥挤和重叠、凹槽、边缘放置的微核oli和多核巨细胞对PTC的诊断意义不大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Accurate Interpretation and Clinical Significance of Morphological Features of Fine Needle Aspiration Cells in Papillary Thyroid Carcinoma.

The Accurate Interpretation and Clinical Significance of Morphological Features of Fine Needle Aspiration Cells in Papillary Thyroid Carcinoma.

Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid gland; fine needle aspiration cytology is the most basic and reliable diagnostic method before PTC operation. However, it is not clear which cell morphological changes can be used as a reliable standard for the diagnosis of PTC. A retrospective analysis was performed on 337 patients with PTC confirmed by postoperative histology. An additional 197 randomly selected patients with benign thyroid lesions were included in the study and used as a control group. True papillary arrangements, swirl arrangements, and escape arrangements had high specificity, all of which were 100%, but only swirl arrangements had ideal sensitivity (77.61%). The nuclear volume characteristics had a high sensitivity of more than 90%, but the specificities of both nuclear crowding and nuclear overlap were too low, only 16.34% and 23.35%. The sensitivities of five nuclear structural characteristics were more than 90%, but only the specificity of intranuclear cytoplasmic pseudoinclusions (INCIs) reached 100%, nuclear contour irregularity and pale nuclei with powdery chromatin also had ideal interpretation value except for grooves and marginally placed micronucleoli. Although the sensitivity of psammoma bodies (PBs) was low, the specificity was 100%. In terms of preparation methods, the method of liquid-based preparation (LBP) is obviously better than that of conventional smears. The diagnostic efficiency by the combined detection method of parallel tests showed that without reducing the specificity, the sensitivity increased with the increase of the number of morphological characteristics and finally reached 98.81%. The INCIs and swirl arrangements are the most common and important indicators for the diagnosis of PTC, whereas papillary-like arrangements, the crowding and overlap of nuclear, grooves, marginally placed micronucleoli, and multinucleated giant cells are of little significance for the diagnosis of PTC.

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来源期刊
Analytical Cellular Pathology
Analytical Cellular Pathology ONCOLOGY-CELL BIOLOGY
CiteScore
4.90
自引率
3.10%
发文量
70
审稿时长
16 weeks
期刊介绍: Analytical Cellular Pathology is a peer-reviewed, Open Access journal that provides a forum for scientists, medical practitioners and pathologists working in the area of cellular pathology. The journal publishes original research articles, review articles, and clinical studies related to cytology, carcinogenesis, cell receptors, biomarkers, diagnostic pathology, immunopathology, and hematology.
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