circRNA 的生物功能和应用--下一代基于 RNA 的疗法。

IF 5.3 2区 生物学 Q2 CELL BIOLOGY
Meiling Sun, Yun Yang
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引用次数: 1

摘要

环状RNA (circRNAs)是一种独特的单链RNA分子,共价封闭,并以组织和细胞特异性的方式表达。大多数环状rna是通过前mrna的反向剪接形成的,在细胞中具有广泛的功能。由于它们缺乏5'帽和3'聚(a)尾,因此它们被归类为非编码rna,充当mirna和rna结合蛋白的海绵。然而,最近的研究发现,一些circrna可以进行帽无关翻译,使它们能够通过替代翻译起始机制编码蛋白质。由于其独特的环状结构,环状rna比线性mrna更稳定。在过去的两年中,基于mRNA的药物受到了极大的关注,mRNA的不稳定性和免疫原性是其广泛应用的主要障碍。由于circRNA比mRNA更稳定,免疫原性更低,可以以组织特异性的方式翻译,因此它是一种很有前途的RNA治疗方式。在本文中,我们将对circRNA的生物学功能和潜在应用进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological functions and applications of circRNAs-next generation of RNA-based therapy.
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来源期刊
CiteScore
9.60
自引率
1.80%
发文量
1383
期刊介绍: The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.
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