Jesús Domínguez-Rojas, Jackeline Caute-Lara, Patrick Caqui-Vilca, Mario Cruz-Arpi, Carlos Martel-Ramírez, Miguel Quispe-Chipana, Abel Sánchez-Rodríguez, Noé Atamari-Anahui
{"title":"未经治疗的HIV患儿侵袭性刚地弓形虫继发的高铁素血症败血症。","authors":"Jesús Domínguez-Rojas, Jackeline Caute-Lara, Patrick Caqui-Vilca, Mario Cruz-Arpi, Carlos Martel-Ramírez, Miguel Quispe-Chipana, Abel Sánchez-Rodríguez, Noé Atamari-Anahui","doi":"10.24875/BMHIM.22000051","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis.</p><p><strong>Case report: </strong>We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution.</p><p><strong>Conclusions: </strong>The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":" ","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hyperferritinemic sepsis secondary to invasive <i>Toxoplasma gondii</i> in a child with untreated HIV.\",\"authors\":\"Jesús Domínguez-Rojas, Jackeline Caute-Lara, Patrick Caqui-Vilca, Mario Cruz-Arpi, Carlos Martel-Ramírez, Miguel Quispe-Chipana, Abel Sánchez-Rodríguez, Noé Atamari-Anahui\",\"doi\":\"10.24875/BMHIM.22000051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis.</p><p><strong>Case report: </strong>We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution.</p><p><strong>Conclusions: </strong>The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.</p>\",\"PeriodicalId\":9103,\"journal\":{\"name\":\"Boletín médico del Hospital Infantil de México\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-03-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Boletín médico del Hospital Infantil de México\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24875/BMHIM.22000051\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Boletín médico del Hospital Infantil de México","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24875/BMHIM.22000051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV.
Background: Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis.
Case report: We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution.
Conclusions: The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.
期刊介绍：
The Boletín Médico del Hospital Infantil de México is a bimonthly publication edited by the Hospital Infantil de México Federico Gómez. It receives unpublished manuscripts, in English or Spanish, relating to paediatrics in the following areas: biomedicine, clinical, public health, clinical epidemology, health education and clinical ethics. Articles can be original research articles, in-depth or systematic reviews, clinical cases, clinical-pathological cases, articles about public health, letters to the editor or editorials (by invitation).
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