成人急性淋巴细胞白血病SLC19A1启动子区甲基化水平与甲氨蝶呤代谢的相关性

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacogenomics Pub Date : 2023-04-01 DOI:10.2217/pgs-2022-0169

Xianqi Huang, Qishan Hao, Qiuyun Fang, Ping Zhang, Hui Wei, Ying Wang, Jianxiang Wang, Yingchang Mi

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引用次数: 0

摘要

目的:分析成人急性淋巴细胞白血病(ALL)患者SLC19A1启动子区甲基化水平，探讨甲氨蝶呤(MTX)药物代谢与SLC19A1甲基化的关系。方法:回顾性分析52例接受大剂量MTX化疗的成人ALL患者SLC19A1启动子区甲基化水平，并结合临床指标和血浆MTX浓度进行分析。结果:17个CpG单位的甲基化水平与ALL患者的性别、年龄、免疫表型和费城染色体状态等临床参数存在不同的相关性。MTX药物排泄延迟的患者在SLC19A1启动子区域的甲基化水平较高。结论:甲基化可能影响MTX血浆水平及不良反应，可预测患者在大剂量MTX治疗后出现不良反应的风险。

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Correlation between methylation level of the SLC19A1 promoter region and methotrexate metabolism in adult acute lymphoblastic leukemia.

Aims: To analyze the methylation level in the promoter region of SLC19A1 in adult acute lymphoblastic leukemia (ALL) patients, and explore the relationship between methotrexate (MTX) drug metabolism and SLC19A1 methylation. Methods: The methylation levels of the SLC19A1 promoter region in 52 adult ALL patients who received high-dose MTX chemotherapy were retrospectively analyzed in combination with clinical indicators and plasma MTX concentration. Results: Methylation levels of 17 CpG units were differently correlated with clinical parameters of ALL patients including gender, age, immunophenotype and Philadelphia chromosome status. Patients with delayed MTX drug excretion had higher methylation levels in the SLC19A1 promoter region. Conclusion: The methylation may affect the MTX plasma level and adverse reactions, which may predict patients at risk of adverse reactions after high-dose MTX therapy.

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.