硬皮病患者心血管疾病风险预测。

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Aliye Çelikkol, Rıdvan Mercan, Savaş Güzel, Ahsen Yılmaz
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引用次数: 0

摘要

目的:对硬皮病患者进行心血管疾病风险预测具有重要意义。本研究以硬皮病患者为研究对象,采用欧洲心脏病学会的系统性冠状动脉风险评估2模型,探讨心肌肌球蛋白结合蛋白- c、敏感肌钙蛋白T和三甲胺n-氧化物与心血管疾病风险的关系。方法:对38例健康对照者和52例硬皮病女性患者的2个危险组进行系统性冠状动脉危险评价。使用商用ELISA试剂盒分析心肌肌球蛋白结合蛋白c、敏感肌钙蛋白T和三甲胺n-氧化物水平。结果:硬皮病患者心肌肌球蛋白结合蛋白- c和三甲胺n-氧化物水平高于健康对照组,而敏感肌钙蛋白T水平低于健康对照组。结论:建议采用系统性冠状动脉风险评价2模型,将硬皮病无创心血管疾病风险预测指标、心肌肌球蛋白结合蛋白- c和三甲胺n-氧化物作为区分高、中危和低危的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cardiovascular disease risk prediction in scleroderma.

Cardiovascular disease risk prediction in scleroderma.

Objective: Cardiovascular disease risk prediction in scleroderma is important. In this study of scleroderma patients, the aim was to investigate the relationship between cardiac myosin-binding protein-C, sensitive troponin T, and trimethylamine N-oxide and cardiovascular disease risk with the Systematic COronary Risk Evaluation 2 model of the European Society of Cardiology.

Methods: Systematic COronary Risk Evaluation 2 risk groups of 38 healthy controls and 52 women with scleroderma were evaluated. Cardiac myosin-binding protein-C, sensitive troponin T, and trimethylamine N-oxide levels were analyzed with commercial ELISA kits.

Results: In scleroderma patients, cardiac myosin-binding protein-C and trimethylamine N-oxide levels were higher than healthy controls but sensitive troponin T was not (p<0.001, p<0.001, and p=0.274, respectively). Out of 52 patients, 36 (69.2%) were at low risk, and the other 16 (30.8%) patients were at high-moderate risk with the Systematic COronary Risk Evaluation 2 model. At the optimal cutoff values, trimethylamine N-oxide could discriminate high-moderate risk with sensitivity 76%, specificity 86% and cardiac myosin-binding protein-C with sensitivity 75%, specificity 83%. Patients with high trimethylamine N-oxide levels (≥10.28 ng/mL) could predict high-moderate- Systematic COronary Risk Evaluation 2 risk 15 times higher than those with low trimethylamine N-oxide (<10.28 ng/mL) levels (odds ratio [OR]: 15.00, 95%CI 3.585-62.765, p<0.001). Similarly, high cardiac myosin-binding protein-C (≥8.29 ng/mL) levels could predict significantly higher Systematic COronary Risk Evaluation 2 risk than low cardiac myosin-binding protein-C (<8.29 ng/mL) levels (OR: 11.00, 95%CI 2.786-43.430).

Conclusion: Noninvasive cardiovascular disease risk prediction indicators in scleroderma, cardiac myosin-binding protein-C, and trimethylamine N-oxide could be recommended to distinguish between high-moderate risk and low risk with the Systematic COronary Risk Evaluation 2 model.

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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
276
审稿时长
12 weeks
期刊介绍: A Revista da Associação Médica Brasileira (RAMB), editada pela Associação Médica Brasileira, desde 1954, tem por objetivo publicar artigos que contribuam para o conhecimento médico.
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