肾淋巴系统在心力衰竭中的作用。

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Husam M Salah, Jan Biegus, Marat Fudim
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引用次数: 2

摘要

综述目的:淋巴系统在维持体液平衡中起着重要但被忽视的作用。鉴于肾脏独特的体液稳态功能,肾淋巴系统的失调是自我繁殖的充血性病理机制发展的基础。在这篇综述中,我们概述了肾淋巴系统在心力衰竭(HF)中的作用。最近发现:研究揭示了充血性肾淋巴系统的几种病理机制,如肾淋巴系统间质引流受损、肾淋巴结构和瓣膜受损、淋巴诱导的肾水钠重吸收增加、蛋白尿诱导的肾淋巴管生成的蛋白尿的发生。这些自我传播机制导致“肾填塞”,表现为心肾综合征和肾脏对利尿剂的不适当反应。肾淋巴系统的失调与心衰充血的发展和进展是不可分割的。靶向肾淋巴可能提供治疗顽固性充血的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of the Renal Lymphatic System in Heart Failure.

Purpose of review: The lymphatic system plays a major but overlooked role in maintaining fluid homeostasis. Given the unique fluid homeostasis functions of the kidneys, dysregulation of the renal lymphatic system underlies the development of self-propagating congestive pathomechanisms. In this review, we outline the roles of the renal lymphatic system in heart failure (HF).

Recent findings: Studies have uncovered several pathomechanisms involving the renal lymphatic system in congestive states, such as impaired interstitial draining by the renal lymphatic system, impaired structure and valves of renal lymphatics, lymphatic-induced increase in renal reabsorption of water and sodium, and development of albuminuria with proteinuria-induced renal lymphangiogenesis. These self-propagating mechanisms result in "renal tamponade" with manifestations of cardiorenal syndrome and inappropriate renal response to diuretics. Dysregulation of the renal lymphatic system is integral to the development and progression of congestion in HF. Targeting renal lymphatics may provide a novel pathway to treat intractable congestion.

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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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