40岁以下心脏性猝死(SCD)病例中法医部门的标准尸检和诊断程序。

Q4 Medicine
Soudni Lekarstvi Pub Date : 2023-01-01
Martin Zeman, Štěpánka Pohlová Kučerová, Tomáš Vojtíšek, Petr Hejna
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引用次数: 0

摘要

年龄小于40岁的心脏性猝死(SCD)在很大一部分病例中有遗传原因。SCD的鉴定、死后基因分析和受害者亲属的心脏病筛查检查是心脏骤停一级预防的重要诊断工具。根据全球和欧洲的建议,在40岁以下的心脏性猝死病例中,尸检结果阴性或不明确,或发现可疑的遗传性心血管疾病,应使用分子遗传学方法进行调查。根据欧洲准则,捷克法医学和法医毒理学学会制定了自己的推荐程序,其中总结了这些病例的鉴定、最佳尸检程序,包括材料的收集,以及对突然死亡的人进行尸检后基因检查的其他必要行动的摘要。这些病例的复杂检查需要多中心和多学科合作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Standard autopsy and diagnostic procedure in forensic departments in cases of sudden cardiac death (SCD) in individuals under 40 years of age.

Sudden cardiac death (SCD) in individuals younger than 40 years has a heritable cause in a significant part of the cases. Identification of SCD, post mortem genetic analysis, and the cardiological screening examination in victim´s relatives represent an important diagnostic tool for the primary prevention of cardiac arrest. Based on global and European recommendations, cases of sudden cardiac death in individuals under the age of 40 with negative or ambiguous autopsy findings, or findings suspicious for hereditary cardiovascular disease, should be investigated using molecular genetic methods. Based on European guidelines, the Czech Society of Forensic Medicine and Forensic Toxicology has developed its own recommended procedure, which summarizes the identification of these cases, the optimal autopsy procedure, including the collection of material, and a summary of other necessary actions for performing a post mortem genetic examination in a person who has died suddenly. Complex examination of these cases requires multicentric and multidisciplinary collaboration.

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Soudni Lekarstvi
Soudni Lekarstvi Medicine-Medicine (all)
CiteScore
0.30
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