紫草生物碱提取物对TPA诱导的小鼠皮肤炎症和氧化应激的抑制作用。

Q2 Medicine

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2023-01-01 DOI:10.2174/1871523022666221212121621

Mohamed Sofiane Merakeb, Noureddine Bribi, Riad Ferhat, Meriem Aziez, Betitera Yanat

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引用次数: 0

摘要

背景:在传统医学中，茴香草治疗炎症、胃肠道和心血管疾病。目的:本研究旨在观察紫草种子总生物碱提取物(ALU)对多次应用TPA诱导的亚慢性炎症模型小鼠耳组织完整性和抗氧化状态的抗炎和抗氧化作用。方法:局部TPA治疗引起各种炎症变化，包括水肿形成、表皮厚度和活性氧的过量产生。组织样品用于测定还原性谷胱甘肽(GSH)和一氧化氮(NO)水平以及髓过氧化物酶(MPO)和过氧化氢酶(CAT)活性。结果:口服ALU(50、100、200 mg/kg)具有抗炎、抗氧化作用。ALU还能显著减少耳部水肿和炎症细胞浸润，恢复耳部的完整性。结论:芡实种子总生物碱提取物对tpa诱导的NMRI小鼠亚慢性炎症模型具有明显的抗炎和抗氧化作用，可作为抗炎和抗氧化剂用于炎性疾病的治疗管理。

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Alkaloids Extract from Linum usitatissimum Attenuates 12-OTetradecanoylphorbol- 13-Acetate (TPA)-induced Inflammation and Oxidative Stress in Mouse Skin.

Background: In traditional medicine, Linum usitatissimum treats inflammatory, gastrointestinal, and cardiovascular diseases.

Objectives: The present study aims to assess the anti-inflammatory and anti-oxidant effects of total alkaloid extract from Linum usitatissimum seeds (ALU) on the ear histological integrity and oxidant- antioxidant status in a mice model of a sub-chronic inflammation induced by multiapplication of TPA.

Methods: Topical TPA treatment induced various inflammatory changes, including edema formation, epidermal thickness, and the excess production of reactive oxygen species. Tissue samples were used for the measurement of reduced glutathione (GSH) and nitric oxide (NO) levels and Myeloperoxidase (MPO) and Catalase (CAT) activities.

Results: Oral administration of ALU (50, 100, and 200 mg/kg) produced anti-inflammatory and anti-oxidant effects. Also, ALU significantly reduced ear edema and inflammatory cell infiltration and restored the integrity of the ear.

Conclusion: These findings suggest that the total alkaloid extract from Linum usitatissimum seeds presents significant anti-inflammatory and anti-oxidant effects on TPA-induced sub-chronic inflammation model in NMRI mice and can be used as an anti-inflammatory and anti-oxidant agent for the therapeutic management of inflammatory disorders.

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.