mRNA疫苗的配方和递送技术。

3区医学 Q2 Medicine

Current topics in microbiology and immunology Pub Date : 2022-01-01 DOI:10.1007/82_2020_217

Chunxi Zeng, Chengxiang Zhang, Patrick G Walker, Yizhou Dong

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引用次数: 110

摘要

mRNA疫苗已成为预防传染病和治疗癌症的通用技术。在疫苗接种过程中，mRNA的形成和递送策略有助于抗原的有效表达和呈递，以及免疫刺激。mRNA疫苗以各种形式递送:通过递送载体(如脂质纳米颗粒、聚合物、多肽、溶液中的游离mRNA)封装，以及通过树突状细胞体外递送。适当的给药材料和配制方法往往能提高疫苗效力，这也受选择适当给药途径的影响。在某些情况下，多个mrna的共同递送可实现协同效应并进一步增强免疫力。在本章中，我们概述了mRNA疫苗的配方和递送技术的最新进展和存在的挑战，并对未来的发展进行了展望。

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Formulation and Delivery Technologies for mRNA Vaccines.

mRNA vaccines have become a versatile technology for the prevention of infectious diseases and the treatment of cancers. In the vaccination process, mRNA formulation and delivery strategies facilitate effective expression and presentation of antigens, and immune stimulation. mRNA vaccines have been delivered in various formats: encapsulation by delivery carriers, such as lipid nanoparticles, polymers, peptides, free mRNA in solution, and ex vivo through dendritic cells. Appropriate delivery materials and formulation methods often boost the vaccine efficacy which is also influenced by the selection of a proper administration route. Co-delivery of multiple mRNAs enables synergistic effects and further enhances immunity in some cases. In this chapter, we overview the recent progress and existing challenges in the formulation and delivery technologies of mRNA vaccines with perspectives for future development.

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.