营养、免疫与衰老:神经退行性疾病的现状与未来展望》。

IF 2.7 4区 医学 Q3 NEUROSCIENCES
Camilla Barbero Mazzucca, Giuseppe Cappellano, Annalisa Chiocchetti
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引用次数: 0

摘要

衰老是生理功能和组织稳态的逐渐衰退,在许多情况下,衰老与(神经)变性和炎症有关,炎症已成为罹患神经变性疾病的最重要风险之一。某些营养素或食物的组合可以通过促进促炎和抗炎反应之间的平衡来抵御衰老和相关的神经退行性疾病。因此,营养可能是这种微妙平衡的一个强有力的调节器,而不是可改变的炎症反应风险因素。这篇叙述性综述从一个广阔的视角探讨了营养对阿尔茨海默病(AD)、帕金森病(PD)和肌萎缩侧索硬化综合征(ALS)的衰老和炎症特征的影响,从营养素到单一食物和复杂的膳食模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nutrition, Immunity and Aging: Current Scenario and Future Perspectives in Neurodegenerative Diseases.

Aging is a gradual decline of physiological function and tissue homeostasis and, in many instances, is related to increased (neuro)-degeneration, together with inflammation, becoming one of the most important risks for developing neurodegenerative diseases. Certain individual nutrients or foods in combination may counteract aging and associated neurodegenerative diseases by promoting a balance between the pro- and anti-inflammatory responses. Thus, nutrition could represent a powerful modulator of this fine balance, other than a modifiable risk factor to contrast inflammaging. This narrative review explores from a broad perspective the impact of nutrition on the hallmarks of aging and inflammation in Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis Syndrome (ALS), starting from nutrients up to single foods and complex dietary patterns.

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来源期刊
CiteScore
5.10
自引率
3.30%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Aims & Scope CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.
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