酒精中毒中氧化应激的特点。

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2023-04-01 DOI:10.18097/PBMC20236902083

V D Prokopieva, T P Vetlugina

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引用次数: 0

摘要

本文综述了酒精依赖患者氧化应激(OS)形成和发展的分子机制。主要关注的是乙醇及其代谢物乙醛的影响，乙醛与外源乙醇产生活性氧(ROS)的额外来源有关。本文介绍了乙醇和乙醛对外周血OS标记物浓度的体外影响的研究结果，这些标记物是蛋白质(蛋白质羰基)、脂质(脂质过氧化产物)、血浆中DNA(8-羟基-2-脱氧鸟苷，8-OHdG)的氧化修饰产物。分析酒精依赖患者这些指标的变化及抗氧化酶(SOD、过氧化氢酶)活性的变化。自身和文献数据表明，在疾病的某一阶段，OS在体内发挥的是保护作用而不是致病作用。

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Features of oxidative stress in alcoholism.

The review considers molecular mechanisms underlying formation and development of oxidative stress (OS) in patients with alcohol dependence. The major attention is paid to the effects of ethanol and its metabolite acetaldehyde associated with additional sources of generation of reactive oxygen species (ROS) in response to exogenous ethanol. The own results of studies of the in vitro effect of ethanol and acetaldehyde on the concentration of peripheral OS markers - products of oxidative modification of proteins (protein carbonyls), lipids (lipid peroxidation products), DNA (8-hydroxy-2-deoxyguanosine, 8-OHdG) in blood plasma are presented. The changes in these parameters and the activity of antioxidant enzymes (SOD, catalase) in patients with alcohol dependence were analyzed. Own and literature data indicate that at a certain stage of the disease OS can play a protective rather than pathogenic role in the body.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).