NOS3基因中内含子4 VNTR多态性与双相情感障碍的研究进展

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurosciences Pub Date : 2023-01-01 DOI:10.17712/nsj.2023.1.20220122

Rujittika Mungmunpuntipantip, Viroj Wiwanitkit, Hasan M Aytac

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Comments on intron 4 VNTR polymorphism in the NOS3 gene and bipolar disorder.

We would like to discuss the recent publication by Aytac et al1 entitled ‘Association of intron 4 VNTR polymorphism in the NOS3 gene with rapid cycling and treatment resistance in bipolar disorder (BD): a case-control study.1 While BD patients with the b/b genotype and b allele had a decreased risk of rapid cycling and treatment resistance, those with the b/a genotype were more at risk for these issues, according to Aytac et al.1 Aytac et al1 also noted that the BD group with the b/b genotype experienced statistically fewer hospitalizations and higher Clinical Global ImpressionImprovement Scale scores than the BD group with the b/a and a/a genotypes.1 The effect of the studied polymorphisms might be detected in the current report. However, it is important to discuss the confounding factors in the present study. At least, there are many genetic polymorphisms that might be related to BD. Examples are UGT1A4 and UGT2B7 Polymorphisms.2 Further studies to assess the effect of those possible confounding polymorphisms should be performed.

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来源期刊

Neurosciences 医学-临床神经学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.