RNA聚合酶II亚基在病毒感染和细胞应激中的调节

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2022-10-01 DOI:10.1016/j.coviro.2022.101259

Leah Gulyas , Britt A Glaunsinger

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引用次数: 1

摘要

基因表达的控制，包括转录，是决定病毒感染结果的核心。病毒引起的深刻改变之一是真核RNA聚合酶II (Pol II)的完整性和功能的修饰。在这里，我们讨论了感染如何通过改变亚基磷酸化和翻转来扰乱Pol II复合体，以及细胞基因毒性应激(例如DNA损伤)如何引起类似的结果。通过强调病毒感染和非生物胁迫期间Pol II控制的相似之处和差异，我们希望加强对靶向Pol II和调节转录组的途径的识别。

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RNA polymerase II subunit modulation during viral infection and cellular stress

Control of gene expression, including transcription, is central in dictating the outcome of viral infection. One of the profound alterations induced by viruses is modification to the integrity and function of eukaryotic RNA polymerase II (Pol II). Here, we discuss how infection perturbs the Pol II complex by altering subunit phosphorylation and turnover, as well as how cellular genotoxic stress (e.g. DNA damage) elicits similar outcomes. By highlighting emerging parallels and differences in Pol II control during viral infection and abiotic stress, we hope to bolster identification of pathways that target Pol II and regulate the transcriptome.

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.