长链非编码RNA DNM3OS在发育和疾病中的普遍作用。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Sandy Fellah, Romain Larrue, Marin Truchi, Georges Vassaux, Bernard Mari, Christelle Cauffiez, Nicolas Pottier
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引用次数: 3

摘要

数千种独特的非编码rna (ncrna)在人类细胞中表达,其中一些是组织或细胞类型特异性的,而另一些则被认为是管家分子。过去十年的研究已经改变了我们对ncrna的看法,从转录噪声到影响各种分子过程的功能调控转录物,如染色质重塑、转录、转录后修饰或信号转导。因此,许多ncrna的异常表达在各种疾病的发生和发展中起着致病作用。长链ncRNA DNM3OS (Dynamin 3 Opposite Strand)自发现其发育作用以来,已引起肿瘤学、纤维增生性疾病或骨疾病等不同领域研究人员的关注。机制研究特别揭示了DNM3OS的多面性及其在几种人类疾病中的重要致病作用。在这篇综述中,我们总结了目前关于DNM3OS在疾病中的功能的知识,重点介绍了它作为一种新的治疗靶点的潜力。本文分类如下:RNA在疾病与发展> RNA在疾病与发展> RNA在疾病与发展> RNA在发展
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pervasive role of the long noncoding RNA DNM3OS in development and diseases.

Thousands of unique noncoding RNAs (ncRNAs) are expressed in human cells, some are tissue or cell type specific whereas others are considered as house-keeping molecules. Studies over the last decade have modified our perception of ncRNAs from transcriptional noise to functional regulatory transcripts that influence a variety of molecular processes such as chromatin remodeling, transcription, post-transcriptional modifications, or signal transduction. Consequently, aberrant expression of many ncRNAs plays a causative role in the initiation and progression of various diseases. Since the identification of its developmental role, the long ncRNA DNM3OS (Dynamin 3 Opposite Strand) has attracted attention of researchers in distinct fields including oncology, fibroproliferative diseases, or bone disorders. Mechanistic studies have in particular revealed the multifaceted nature of DNM3OS and its important pathogenic role in several human disorders. In this review, we summarize the current knowledge of DNM3OS functions in diseases, with an emphasis on its potential as a novel therapeutic target. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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