日本第二次和第三次接种BNT162b2疫苗后与高IgG抗体滴度相关的发热反应。

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-04-28 DOI:10.7883/yoken.JJID.2022.677
Nobuyasu Wakazono, Katsura Nagai, Arei Mizushima, Yukiko Maeda, Natsuko Taniguchi, Toshiyuki Harada, Emiko Satou, Nao Mae, Ken Furuya
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引用次数: 0

摘要

接种严重急性呼吸综合征冠状病毒2型BNT162b2疫苗后,不良事件可能与IgG反应有关。在本研究中,我们使用健康问卷调查了BNT162b2疫苗的副作用,并检查了其与IgG抗体滴度的关系。在第二次疫苗接种后3个月、第三次疫苗接种前以及第三次接种后1个月和3个月采集参与者的血清样本。共有505名接种了三剂疫苗的参与者有资格纳入分析。结果显示,接种后体温与第二次(r=0.30,P<0.001)和第三次(r=0.14,P<0.000)接种后3个月测得的抗刺突受体结合域(抗S-RBD)抗体滴度相关。多元线性回归分析显示,年龄和严重肿胀呈负相关,而女性、体温和热感与第二次疫苗接种后log转化的抗S-RBD抗体水平呈正相关。第三次接种疫苗后,体温和疲劳与log转化的抗S-RBD抗体水平呈正相关,而女性与之呈负相关。这些结果表明,接种疫苗后的发烧可能是高抗体滴度的标志。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Febrile Reactions Associated with High IgG Antibody Titers after the Second and Third BNT162b2 Vaccinations in Japan.

Adverse events are potentially associated with an IgG response after BNT162b2 vaccination for severe acute respiratory syndrome coronavirus 2. In this study, we investigated the side effects of the BNT162b2 vaccine using a health questionnaire and examined its relationship with IgG antibody titers. Serum samples were collected from participants 3 months after the second vaccination, immediately before the third vaccination, and 1 and 3 months after the third vaccination. A total of 505 participants who received three doses of vaccine were eligible for inclusion in the analysis. The results showed that post-vaccination body temperature correlated with anti-spike-receptor-binding domain (anti-S-RBD) antibody titers measured 3 months after the second (r = 0.30, P < 0.001) and third (r = 0.14, P < 0.001) vaccinations. Multivariate linear regression analysis revealed that age and severe swelling were negatively associated, whereas female sex, body temperature, and heat sensation were positively associated with log-transformed anti-S-RBD antibody levels after the second vaccination. After the third vaccination, body temperature and fatigue were positively associated, and female sex was negatively associated, with the log-transformed anti-S-RBD antibody levels. These results suggest that post-vaccination fever may be a marker of a high antibody titer.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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