情绪刺激对焦虑障碍脑激活的影响及fMRI ALE meta分析。

IF 0.6 4区医学 Q4 CLINICAL NEUROLOGY

Neurocase Pub Date : 2022-10-01 DOI:10.1080/13554794.2022.2160262

Xia Liu, Guowei Zheng, Xiuzhen Wang, Yongchao Li, Shanling Ji, Yu Zhang, Chaofan Yao, Yinghui Zhang, Bin Hu

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引用次数: 0

摘要

大量研究分析了情绪刺激下焦虑障碍的大脑激活状态。然而，目前还没有meta分析来评估不同亚型焦虑的共性和特异性激活。在这里，我们使用ALE进行评估。29项研究发现，在情绪刺激下，焦虑障碍患者的双侧杏仁核、前扣带回、海马旁回的激活增加。此外，我们观察到后扣带、舌回和楔前叶的激活减少。在亚分析中，虽然不同的焦虑表现出不同的激活，但主要的激活出现在边缘叶，这可能表明边缘回路是焦虑症状的主要神经反应。

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The brain activation of anxiety disorders with emotional stimuli-an fMRI ALE meta-analysis.

Numerous studies have analyzed the state of brain activation about anxiety disorders under emotional stimuli. However, there is no meta-analysis to assess the commonality and specificity activation concerning different subtypes of anxiety. Here, we used ALE to assess this. 29 studies revealed increased bilateral amygdala, anterior cingulate gyrus, parahippocampal gyrus activation in anxiety disorders during emotional stimuli. Moreover, we observed decreased activations in the posterior cingulate, lingual gyrus, and precuneus. In sub-analysis, although different anxiety showed dissimilar activations, the principal activations were observed in limbic lobe, which might indicate the limbic circuit was the main neural reflection of anxiety symptoms.

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来源期刊

Neurocase 医学-精神病学

CiteScore

1.40

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurocase is a rapid response journal of case studies and innovative group studies in neuropsychology, neuropsychiatry and behavioral neurology that speak to the neural basis of cognition. Four types of manuscript are considered for publication: single case investigations that bear directly on issues of relevance to theoretical issues or brain-behavior relationships; group studies of subjects with brain dysfunction that address issues relevant to the understanding of human cognition; reviews of important topics in the domains of neuropsychology, neuropsychiatry and behavioral neurology; and brief reports (up to 2500 words) that replicate previous reports dealing with issues of considerable significance. Of particular interest are investigations that include precise anatomical localization of lesions or neural activity via imaging or other techniques, as well as studies of patients with neurodegenerative diseases, since these diseases are becoming more common as our population ages. Topic reviews are included in most issues.