使用改良版GE Q肺验证RAH VQ SPECT/CT大叶定量程序。

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2023-01-01 DOI:10.1967/s002449912551

Chong Ghee Chew, Benjamin Crouch, Stirling Ha, Alice Burke, Jennie Louise

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引用次数: 0

摘要

目的:了解通气灌注(VQ)单光子发射断层扫描/计算机断层扫描(SPECT/CT)肺叶定量在肺叶切除术和肺减容术前评估中的价值。我们内部开发的软件RAH通气灌注SPECT/CT量化(RAHVQSQ)已被证明能够识别晚期肺气肿支气管镜肺减容(BLVR)中塌陷的靶叶。我们已经证明了观察者之间和内部的可重复性，但尚未验证我们程序的准确性。本研究旨在通过与GE Q肺的改良版本进行比较来验证我们定量程序的准确性，GE Q肺是一个经临床应用认证的商业程序。受试者和方法:我们之前使用RAHVQSQ进行BLVR评估的19名受试者的通气-灌注SPECT/CT数据由2名技术人员独立地以盲法使用Q肺重新分析，以确定大叶差异通气，灌注和容积百分比。数据来自GE Hawkeye 4和外置CT，因此使用改良版的Q肺。为了确定3个评估者之间3个参数的观察者间变异，我们生成了类内相关系数(ICC)和Bland-Altman一致限(LoA)。结果:3名评估者的配对比较具有较高的ICC(通气范围:0.69-0.97;灌注:0.69 - -0.97;容积:0.63-0.97)，LoA平均值差接近于零(通风范围:-0.04 - 0.10;灌注:0.00 - -0.02;体积:-0.12 - 0.09)表明所有参数的一致性良好。结论:使用晚期气道疾病参与者的VQ SPECT/CT数据，我们的研究发现，与使用Q肺的重复盲法评估相比，使用RAHVQSQ估计的差异肺叶通气、灌注和容积百分比具有密切的一致性。良好的一致性支持了我们定量方法的有效性。

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Validation of RAH VQ SPECT/CT lobar quantification program using a modified version of GE Q lung.

Objective: The value of ventilation-perfusion (VQ) single photon emission tomography/computed tomography (SPECT/CT) lobar quantification for pre-operative assessment of lobectomy and lung volume reduction is known. Our in-house developed software, RAH ventilation perfusion SPECT/CT quantification (RAHVQSQ) has been shown to be able to identify the target lobe for collapse in bronchoscopic lung volume reduction (BLVR) for advanced emphysema. We have proven inter and intra observer reproducibility but are yet to validate the accuracy of our program. This study aims to validate the accuracy of our quantitative program through comparison with a modified version of GE Q lung which is a commercial program certified for clinical use.

Subjects and methods: Ventilation-perfusion SPECT/CT data of 19 subjects from our previous study using RAHVQSQ for BLVR assessment were re-analysed using Q lung by 2 technologists independently and in a blinded fashion to determine lobar differential ventilation, perfusion and volume percentages. The data were from GE Hawkeye 4 and external CT, thus a modified version of Q lung was used. To determine interobserver variation in the 3 parameters between the 3 assessors, intraclass correlation coefficient (ICC) and Bland-Altman limits of agreement (LoA) were generated.

Results: Paired comparisons between the 3 assessors had high ICC (range for ventilation: 0.69-0.97; perfusion: 0.69-0.97; volume: 0.63-0.97) and means of LoA differences close to zero (range for ventilation: -0.04 - 0.10; perfusion: 0.00-0.02; volume: -0.12 - 0.09) were noted indicative of good concordance for all parameters.

Conclusion: Using VQ SPECT/CT data of participants with advanced airway disease, our study has found a close concordance of estimated differential lobar ventilation, perfusion and volume percentages using RAHVQSQ when compared with a duplicated blinded assessment using Q lung. The good concordance supports the validity of our quantitative methodology.

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.