器官移植受者皮肤鳞状细胞癌的肿瘤免疫微环境。

IF 1.5 4区医学 Q3 DERMATOLOGY

Annals of Dermatology Pub Date : 2023-04-01 DOI:10.5021/ad.22.175

Catherine Zilberg, James Guy Lyons, Ruta Gupta, Angela Ferguson, Diona Lee Damian

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引用次数: 0

摘要

皮肤鳞状细胞癌(cSCC)是免疫抑制器官移植受体(OTRs)中最常见的恶性肿瘤。虽然其他恶性肿瘤(皮肤和非皮肤)的发病率在这一人群中有所上升，但增幅远没有那么显著。提示cSCC一定是一种高度免疫原性肿瘤。OTRs引起的cSCC肿瘤免疫微环境发生改变。它降低了抗肿瘤的特性，反而提供了一个促进肿瘤生长和存活的环境。了解来自OTRs的cSCC肿瘤免疫微环境的组成和功能有助于预后和治疗决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Tumor Immune Microenvironment in Cutaneous Squamous Cell Carcinoma Arising in Organ Transplant Recipients.

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The Tumor Immune Microenvironment in Cutaneous Squamous Cell Carcinoma Arising in Organ Transplant Recipients.

Cutaneous squamous cell carcinoma (cSCC) is the most common malignancy in immune-suppressed organ transplant recipients (OTRs). Whilst rates of other malignancies (both cutaneous and non-cutaneous) are elevated in this population, the increase is far less striking. This suggests that cSCC must be a highly immunogenic tumor. The tumor immune microenvironment is altered in cSCC from OTRs. It has reduced anti-tumor properties and instead provides an environment that facilitates tumor growth and survival. Understanding the composition and function of the tumor immune microenvironment in cSCC from OTRs is useful for prognostication and therapeutic decisions.

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来源期刊

Annals of Dermatology 医学-皮肤病学

CiteScore

1.60

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Annals of Dermatology (Ann Dermatol) is the official peer-reviewed publication of the Korean Dermatological Association and the Korean Society for Investigative Dermatology. Since 1989, Ann Dermatol has contributed as a platform for communicating the latest research outcome and recent trend of dermatology in Korea and all over the world. Ann Dermatol seeks for ameliorated understanding of skin and skin-related disease for clinicians and researchers. Ann Dermatol deals with diverse skin-related topics from laboratory investigations to clinical outcomes and invites review articles, original articles, case reports, brief reports and items of correspondence. Ann Dermatol is interested in contributions from all countries in which good and advanced research is carried out. Ann Dermatol willingly recruits well-organized and significant manuscripts with proper scope throughout the world.