Amadeusz Odroniec, Marta Olszewska, Maciej Kurpisz
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引用次数: 0
摘要
精子发生是由睾丸曲细精管上皮细胞中的精原细胞干细胞生成男性生殖细胞的过程。在精子发生过程中，干细胞自我更新和进入减数分裂、减数分裂重组、减数分裂性染色体失活等关键的生精事件会发生，随后拉长的精子细胞会发生细胞和染色质重塑，从而产生精子细胞。所有上述事件至少有一部分是由 DNA 和组蛋白的表观遗传修饰控制的。此外，在原始生殖细胞的胚胎发育过程中，也会发生 DNA 的整体表观遗传重编程。在这篇综述中，我们总结了生殖细胞发育特定阶段DNA和组蛋白中最重要的表观遗传修饰，这些修饰从原始生殖细胞开始，在胚胎发育过程中进行，最后在精子形成过程中发生组蛋白到质粒的转变。
Epigenetic markers in the embryonal germ cell development and spermatogenesis.
Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, meiotic recombination, meiotic sex chromosome inactivation, followed by cellular and chromatin remodeling of elongating spermatids occur, leading to sperm cell production. All the mentioned events are at least partially controlled by the epigenetic modifications of DNA and histones. Additionally, during embryonal development in primordial germ cells, global epigenetic reprogramming of DNA occurs. In this review, we summarized the most important epigenetic modifications in the particular stages of germ cell development, in DNA and histone proteins, starting from primordial germ cells, during embryonal development, and ending with histone-to-protamine transition during spermiogenesis.
期刊介绍：
Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.
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