类风湿关节炎靶向成纤维细胞样滑膜细胞

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2022-12-01 DOI:10.1016/j.coph.2022.102304

Vladislav Tsaltskan, Gary S. Firestein

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引用次数: 12

摘要

成纤维细胞样滑膜细胞(FLS)是间充质来源的细胞，通过产生滑膜液和关节软骨的某些成分，在滑膜生理中起重要作用。然而，在类风湿性关节炎(RA)中，成纤维细胞成为滑膜炎症和关节损伤的关键驱动因素。正因为如此，最近人们对FLS作为RA的治疗靶点产生了兴趣，以避免与许多现有RA治疗相关的全身免疫抑制等副作用。在这篇综述中，我们描述了已批准的RA治疗方法如何影响FLS信号传导和功能，并讨论了正在研究的FLS靶向药物对RA的影响。

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Targeting fibroblast-like synoviocytes in rheumatoid arthritis

Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role in the physiology of the synovium by producing certain components of the synovial fluid and articular cartilage. In rheumatoid arthritis (RA), however, fibroblasts become a key driver of synovial inflammation and joint damage. Because of this, there has been recent interest in FLS as a therapeutic target in RA to avoid side effects such as systemic immune suppression associated with many existing RA treatments. In this review, we describe how approved treatments for RA affect FLS signaling and function and discuss the effects of investigational FLS-targeted drugs for RA.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.