他汀类药物在高危心血管患者中的应用:一项横断面研究

IF 2.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Yusuf Cetin Doganer, Umit Aydogan, Umit Kaplan, Suat Gormel, James Edwin Rohrer, Uygar Cagdas Yuksel
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引用次数: 0

摘要

目的:他汀类药物的依从性是一个重要的问题,尽管终生用药是推荐的,特别是对心血管高危患者。感知风险作为心脏病患者依从性预测因子的重要性尚未得到充分探讨。本研究旨在测试感知风险作为高胆固醇血症患者他汀类药物依从性预测因子的重要性,以确定与依从性差相关的预测因子。方法:本横断面研究在土耳其安卡拉大学医院心脏病科门诊进行。总共招募了327名连续的高CV风险患者。Morisky Green Levine药物依从性量表用于评估他汀类药物的依从性。结果:34.5%的患者担心副作用。平均年龄63.85±11.29岁,男性占66.1%,非药物替代治疗占32.4%,地中海饮食占53.2%,不定期检查血脂值占20.8%。参与者报告50.2%高,30%中等,19.9%低他汀类药物依从性。低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白(HDL)控制率分别为44.6%、74.3%、61.5%和41.6%。在多元逻辑回归中,对副作用的关注与统计学上显著的四倍不依从性升高相关。此外,男性,前吸烟者,没有补充干预,定期就诊,受教育超过5年,抑郁症状得分低,生活在农村,从未或曾经吸烟,员工是高药物依从性得分的重要预测因素。结论:大约一半的患者报告高药物依从性。提高依从性的适当策略包括对患者进行教育,重点关注那些担心副作用的患者,以及那些女性、受教育程度较低、目前吸烟、对补充干预感兴趣、不定期随访和有抑郁症状的患者。简短的药物依从性量表有助于评估患者的依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Statin adherence in patients with high cardiovascular risk: a cross-sectional study.

Objectives: Statin adherence is an essential problem although lifetime medication is recommended especially in patients with high cardiovascular risk. The importance of perceived risk as a predictor of adherence among cardiology patients has not been fully explored. This study aimed to test the importance of perceived risk as a predictor of statin adherence amongst hypercholesterolemic patients to identify predictors associated with poor adherence.

Methods: This cross-sectional study was conducted at cardiology outpatient clinics of the University hospital in Ankara, Turkey. A total of 327 consecutive patients with high CV risk were recruited. Self-reported Morisky Green Levine Medication Adherence Scale was used to assess statin adherence.

Results: Of the patients studied, 34.5% had concerns about side effects. Also, the mean age was 63.85 ± 11.29 years, 66.1% were men, 32.4% applied non-drug alternative therapies, 53.2% had a Mediterranean-style diet and 20.8% checked their lipid values irregularly. Participants reported 50.2% high, 30% moderate, and 19.9% low statin medication adherence. Low-density lipoprotein cholesterol (LDL-C), Total Cholesterol (TC), Triglyceride (TG) and high-density lipoprotein (HDL) control rates were 44.6%, 74.3%, 61.5% and 41.6%. On multiple logistic regression, concern about side effects was associated with a statistically significant quadruple elevation of odds of non-adherence. Also, being male, former smokers, not having complementary interventions, having regular visits, being educated for more than 5 years, having low depressive symptom scores, living in a rural, being never or former smokers, employee were significant predictors of high medication adherence scores.

Conclusion: Approximately half of the patients reported high medication adherence. Proper strategies to improve adherence would include patient education efforts focused on patients with concerns about side effects and those who are female, less educated, current smokers, interested in complementary interventions, have irregular follow-up visits, and have depressive symptoms. Brief medication adherence scales may facilitate the assessment of patients' adherence.

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来源期刊
Postgraduate Medicine
Postgraduate Medicine 医学-医学:内科
CiteScore
6.10
自引率
2.40%
发文量
110
审稿时长
6-12 weeks
期刊介绍: Postgraduate Medicine is a rapid peer-reviewed medical journal published for physicians. Tracing its roots back to 1916,  Postgraduate Medicine  was established by Charles Mayo, MD, as a peer-to-peer method of communicating the latest research to aid physicians when making treatment decisions, and it maintains that aim to this day. In addition to its core subscriber base, Postgraduate Medicine is distributed to hundreds of US-based physicians within internal medicine and family practice.
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