阿尔茨海默病乙酰胆碱酯酶抑制剂治疗后Theta正常化但Gamma活动增加:初步qEEG研究

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Ezgi Fide, Deniz Yerlikaya, Didem Öz, İbrahim Öztura, Görsev Yener
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引用次数: 2

摘要

乙酰胆碱酯酶抑制剂(ache - 1)是轻至重度阿尔茨海默病(AD)的核心治疗药物。然而,ache - 1治疗对脑电图(EEG)和认知的影响尚不清楚。我们的目的是调查脑电图功率和连贯性的变化,除了神经心理表现,经过一年的治疗。纳入了9名新生AD患者和人口统计学匹配的健康对照(HC)。基线评估后,所有AD参与者开始接受胆碱能治疗。我们发现基线和随访的伽马功率分析在两组之间是相似的。然而,在摄入ache - 1后的AD组中,AD患者表现出比基线更高的伽马能量(P P P)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Normalized Theta but Increased Gamma Activity after Acetylcholinesterase Inhibitor Treatment in Alzheimer's Disease: Preliminary qEEG Study.

Acetylcholinesterase inhibitors (AChE-I) are the core treatment of mild to severe Alzheimer's disease (AD). However, the efficacy of AChE-I treatment on electroencephalography (EEG) and cognition remains unclear. We aimed to investigate the EEG power and coherence changes, in addition to neuropsychological performance, following a one-year treatment. Nine de-novo AD patients and demographically-matched healthy controls (HC) were included. After baseline assessments, all AD participants started cholinergic therapy. We found that baseline and follow-up gamma power analyzes were similar between groups. Yet, within the AD group after AChE-I intake, individuals with AD displayed higher gamma power compared to their baselines (P < .039). Also, baseline gamma coherence analysis showed lower values in the AD than in HC (P < .048), while these differences disappeared with increased gamma values of AD patients at the follow-up. Within the AD group after AChE-I intake, individuals with AD displayed higher theta and alpha coherence compared to their baselines (all, P < .039). These increased results within the AD group may result from a subclinical epileptiform activity. Even though AChE-I is associated with lower mortality, our results showed a significant effect on EEG power yet can increase the subclinical epileptiform activity. It is essential to be conscious of the seizure risk that treatment may cause.

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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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