{"title":"海洋源真菌曲霉中的新型吲哚二酮哌嗪立体异构体","authors":"Xinyang Li, Jinzhong Xu, Pinmei Wang, Wanjing Ding","doi":"10.1080/21501203.2022.2069173","DOIUrl":null,"url":null,"abstract":"<p><p>Four dimeric diketopiperazine stereoisomers (<b>1-4</b>) including two new ones (<b>1-2</b>) had been isolated from the culture broth of one marine-derived fungus <i>Aspergillus</i> sp. Z3, which was found in the gut of a marine isopod <i>Ligia exotica</i>. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey's method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930829/pdf/","citationCount":"0","resultStr":"{\"title\":\"Novel indole diketopiperazine stereoisomers from a marine-derived fungus <i>Aspergillus</i> sp.\",\"authors\":\"Xinyang Li, Jinzhong Xu, Pinmei Wang, Wanjing Ding\",\"doi\":\"10.1080/21501203.2022.2069173\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Four dimeric diketopiperazine stereoisomers (<b>1-4</b>) including two new ones (<b>1-2</b>) had been isolated from the culture broth of one marine-derived fungus <i>Aspergillus</i> sp. Z3, which was found in the gut of a marine isopod <i>Ligia exotica</i>. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey's method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.</p>\",\"PeriodicalId\":18833,\"journal\":{\"name\":\"Mycology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2022-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930829/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21501203.2022.2069173\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MYCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21501203.2022.2069173","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MYCOLOGY","Score":null,"Total":0}
Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp.
Four dimeric diketopiperazine stereoisomers (1-4) including two new ones (1-2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey's method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.
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