海洋源真菌曲霉中的新型吲哚二酮哌嗪立体异构体

IF 4.6 2区 生物学 Q1 MYCOLOGY
Mycology Pub Date : 2022-04-29 eCollection Date: 2023-01-01 DOI:10.1080/21501203.2022.2069173
Xinyang Li, Jinzhong Xu, Pinmei Wang, Wanjing Ding
{"title":"海洋源真菌曲霉中的新型吲哚二酮哌嗪立体异构体","authors":"Xinyang Li, Jinzhong Xu, Pinmei Wang, Wanjing Ding","doi":"10.1080/21501203.2022.2069173","DOIUrl":null,"url":null,"abstract":"<p><p>Four dimeric diketopiperazine stereoisomers (<b>1-4</b>) including two new ones (<b>1-2</b>) had been isolated from the culture broth of one marine-derived fungus <i>Aspergillus</i> sp. Z3, which was found in the gut of a marine isopod <i>Ligia exotica</i>. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey's method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"14 1","pages":"1-10"},"PeriodicalIF":4.6000,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930829/pdf/","citationCount":"0","resultStr":"{\"title\":\"Novel indole diketopiperazine stereoisomers from a marine-derived fungus <i>Aspergillus</i> sp.\",\"authors\":\"Xinyang Li, Jinzhong Xu, Pinmei Wang, Wanjing Ding\",\"doi\":\"10.1080/21501203.2022.2069173\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Four dimeric diketopiperazine stereoisomers (<b>1-4</b>) including two new ones (<b>1-2</b>) had been isolated from the culture broth of one marine-derived fungus <i>Aspergillus</i> sp. Z3, which was found in the gut of a marine isopod <i>Ligia exotica</i>. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey's method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.</p>\",\"PeriodicalId\":18833,\"journal\":{\"name\":\"Mycology\",\"volume\":\"14 1\",\"pages\":\"1-10\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2022-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930829/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21501203.2022.2069173\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MYCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21501203.2022.2069173","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

从一种海洋源真菌 Aspergillus sp. Z3 的培养液中分离出了四种二元二酮哌嗪立体异构体(1-4),其中包括两种新化合物(1-2)。新化合物的平面结构和绝对构型是通过核磁共振、HRESIMS、电子圆二色性计算、马菲法以及单晶 X 射线衍射等方法确定的。它们对前列腺癌 PC3 细胞株的细胞毒性采用 MTT 法进行了检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Novel indole diketopiperazine stereoisomers from a marine-derived fungus <i>Aspergillus</i> sp.

Novel indole diketopiperazine stereoisomers from a marine-derived fungus <i>Aspergillus</i> sp.

Novel indole diketopiperazine stereoisomers from a marine-derived fungus <i>Aspergillus</i> sp.

Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp.

Four dimeric diketopiperazine stereoisomers (1-4) including two new ones (1-2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey's method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Mycology
Mycology Medicine-Infectious Diseases
CiteScore
9.10
自引率
0.00%
发文量
18
审稿时长
13 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信