肿瘤分子表型对胃癌根治术后患者生存的影响。

Q3 Medicine

Experimental oncology Pub Date : 2022-12-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-4.18903

Yu V Dumanskyi, S I Kirkilevskyi, O M Sulaeva, V O Polyasnyi, A O Mashukov, L A Kovalevska, R R Yarema, M A Ogorchak

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引用次数: 0

摘要

胃癌(GC)的治疗策略，特别是扩大手术干预的使用在不同国家有所不同。在比较治疗结果时，不同人群中特定分子GC亚型的不同比例通常不被考虑在内。本初步研究分析了肿瘤分子亚型对胃癌患者长期联合手术干预后生存率的影响。弥漫性癌症类型(p53-， VEGFR+， HER2/neu+， Ki-67+表型)患者的生存率得到改善。作者提出了认识GC分子异质性的重要性的观点。关键词:胃癌，分子分类，肿瘤生物学

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IMPACT OF TUMOR MOLECULAR PHENOTYPE ON SURVIVAL OF PATIENTS WITH GASTRIC CANCER AFTER RADICAL SURGERY.

The strategy for the treatment of gastric cancer (GC), in particular the use of the extended surgical interventions in different countries varies. The different proportion of specific molecular GC subtypes in various populations frequently is not taken into account for comparing treatment outcomes. This pilot study analyzes the association of survival of GC patients after the extended combined surgical interventions depending on the molecular subtype of the tumors. An improved survival for patients with diffuse cancer types (p53-, VEGFR⁺, HER2/neu⁺, Ki-67⁺ phenotype) was demonstrated. The authors propose their point of view on the importance of recognizing GC molecular heterogeneity.Key Words: gastric cancer, molecular classification, tumor biology.

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.