睾丸间皮瘤的分子特征及石棉作为致病因素的作用。

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Ashleigh Jean Hocking, Elaine May Thomas, Sarita Prabhakaran, Alexandra Jolley, Susan Lesley Woods, Matthew J Soeberg, Sonja Klebe
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引用次数: 1

摘要

上下文。摘要:阴道睾丸膜间皮瘤(TVT)是一种极为罕见的间皮瘤。-:比较TVT间皮瘤与其他更常见部位间皮瘤的临床和分子特征,包括与石棉接触的关系。我们报告9例原发性TVT间皮瘤的临床和病理资料。我们首次对3例患者进行了全基因组测序。-: 9例TVT间皮瘤中有7例为上皮样,其余2例为双相形态。形态学和免疫组织化学特征与其他地方的间皮瘤难以区分。9例中有7例记录了石棉暴露,2例没有任何信息。经全基因组测序的3例TVT间皮瘤病例显示出与其他部位间皮瘤相似的突变谱,包括NF2和TP53突变。-: TVT间皮瘤的临床和分子特征与其他间皮瘤相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor.

Context.—: Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma.

Objective.—: To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos.

Design.—: We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time.

Results.—: The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations.

Conclusions.—: The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.

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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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