分化和功能在内分泌肿瘤中的独特重要性。

IF 11.3 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-04-12 DOI:10.1007/s12022-023-09762-4
Sylvia L Asa, Silvia Uccella, Arthur Tischler
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引用次数: 0

摘要

对内分泌肿瘤细胞分化的评估不仅涉及细胞结构的鉴定和调控细胞的特定转录因子的表达,还涉及激素和/或参与激素合成的酶的鉴定。由于激素可作为生物标志物用于临床监测,以确定疾病的持续、复发或进展情况,这就强调了这种功能特征描述的重要性。有时,激素表达的异常模式会导致意想不到的临床症状和体征。随着肿瘤变得更具侵袭性,分化激素分泌的丧失可能是去分化的标志。除了预后信息外,细胞分化还具有预测作用,因为分化的内分泌细胞会表达治疗靶点,如甲状腺癌中的碘化钠合酶和神经内分泌肿瘤中的体生长抑素受体。三种主要内分泌细胞分化的突出特点可用于确定预后,并对内分泌肿瘤患者进行有针对性的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Unique Importance of Differentiation and Function in Endocrine Neoplasia.

The Unique Importance of Differentiation and Function in Endocrine Neoplasia.

The assessment of cell differentiation in endocrine neoplasms involves not only the identification of a cell's structure and expression of specific transcription factors which regulate that cell, but also the identification of hormones and/or enzymes involved in hormone synthesis. The importance of this functional characterization is emphasized by the fact that the hormones serve as biomarkers for clinical surveillance to identify persistence, recurrence, or progression of disease. Sometimes, unusual patterns of hormone expression lead to unexpected clinical signs and symptoms. Loss of differentiated hormone production can be a sign of dedifferentiation as a tumor becomes more aggressive. In addition to prognostic information, cell differentiation can be predictive, since differentiated endocrine cells express targets for therapy, such as the sodium iodide symporter in thyroid cancers and somatostatin receptors in neuroendocrine tumors. The salient features of differentiation in the three main types of endocrine cells can be used to determine prognosis and to tailor management of patients with endocrine neoplasms.

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来源期刊
Endocrine Pathology
Endocrine Pathology 医学-病理学
CiteScore
12.30
自引率
20.50%
发文量
41
审稿时长
>12 weeks
期刊介绍: Endocrine Pathology publishes original articles on clinical and basic aspects of endocrine disorders. Work with animals or in vitro techniques is acceptable if it is relevant to human normal or abnormal endocrinology. Manuscripts will be considered for publication in the form of original articles, case reports, clinical case presentations, reviews, and descriptions of techniques. Submission of a paper implies that it reports unpublished work, except in abstract form, and is not being submitted simultaneously to another publication. Accepted manuscripts become the sole property of Endocrine Pathology and may not be published elsewhere without written consent from the publisher. All articles are subject to review by experienced referees. The Editors and Editorial Board judge manuscripts suitable for publication, and decisions by the Editors are final.
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