MAOA、COMT、DRD4和5HT2A基因多态性携带者对情绪和中性视觉场景的识别

IF 1.1 Q3 PSYCHOLOGY, MULTIDISCIPLINARY
Pavel N Ermakov, Elena V Vorobyeva, Ekaterina G Denisova, Denis V Yavna, Vitali V Babenko, Ekaterina M Kovsh, Daria S Alekseeva
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引用次数: 0

摘要

背景:众所周知,一些基因调节神经化学代谢,它们的多态性影响认知表现,包括对情感重要信息进行分类的能力。目的:本研究旨在分析MAOA、COMT、DRD4和5HT2A基因不同多态性变异携带者对情绪和中性视觉场景的识别。设计:研究样本由87名大学生组成(白种人,女性63%,平均年龄20.4±2.6岁)。采用聚合酶链反应测定COMT、5HT2A和DRD4基因的基因型。琼脂糖凝胶电泳测定MAOA基因串联重复数。360张不同情绪效价(积极的、消极的和中性的——每一类120张)的场景照片被用作刺激。这些图像经过专家评估分类。这些图像按随机顺序呈现。曝光时间为700 ms。研究参与者被要求确定每个场景的情感效价。结果:我们发现只有COMT基因型影响情感和中性视觉场景的识别。COMT Val/Val基因型使多巴胺在突触空间停留的时间更短,携带这种基因型的人对场景的情感内容的识别能力更强,敏感性更高。Val/Met基因型携带者区分视觉场景情感效价的能力最差。结论:本研究表明单胺类化合物在COMT基因调控的突触空间中停留的时间长短影响情绪视觉信息的识别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recognition of Emotional and Neutral Visual Scenes in Carriers of the MAOA, COMT, DRD4, and 5HT2A Gene Polymorphisms.

Recognition of Emotional and Neutral Visual Scenes in Carriers of the MAOA, COMT, DRD4, and 5HT2A Gene Polymorphisms.

Recognition of Emotional and Neutral Visual Scenes in Carriers of the MAOA, COMT, DRD4, and 5HT2A Gene Polymorphisms.

Background: It is known that some genes regulate neurochemical metabolism, and their polymorphisms affect cognitive performance, including the ability to categorize emotionally significant information.

Objective: The aim of our study was to analyze the recognition of emotional and neutral visual scenes in carriers of different polymorphic variants of the MAOA, COMT, DRD4, and 5HT2A genes.

Design: The study sample consisted of 87 university students (Caucasians, women 63%, average age 20.4±2.6 years). The genotypes of the COMT, 5HT2A, and DRD4 genes were determined by polymerase chain reaction. Agarose gel electrophoresis was used to determine the number of tandem repeats of the MAOA gene. Three hundred sixty (360) photographic images of scenes of different emotional valence (positive, negative, and neutral - 120 images for each category) were used as stimuli. These images were classified by expert assessments. The images were presented in a random sequence. The exposure time was 700 ms. The research participants were asked to determine the emotional valence of each scene.

Results: We found that only the COMT gene genotype affected the recognition of emotional and neutral visual scenes. Carriers of the COMT Val/Val genotype, which causes dopamine to stay in the synaptic space for a shorter time, are better in recognizing and demonstrate higher sensitivity to the emotional content of scenes. Carriers of the Val/Met genotype demonstrated the worst ability to differentiate the emotional valence of visual scenes.

Conclusion: This study has shown that the length of stay of monoamines in the synaptic space regulated by the COMT gene affects the recognition of emotional visual information.

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来源期刊
Psychology in Russia-State of the Art
Psychology in Russia-State of the Art PSYCHOLOGY, MULTIDISCIPLINARY-
CiteScore
2.00
自引率
11.10%
发文量
11
审稿时长
14 weeks
期刊介绍: Established in 2008, the Russian Psychological Society''s Journal «Psychology in Russia: State of the Art» publishes original research on all aspects of general psychology including cognitive, clinical, developmental, social, neuropsychology, psychophysiology, psychology of labor and ergonomics, and methodology of psychological science. Journal''s list of authors comprises prominent scientists, practitioners and experts from leading Russian universities, research institutions, state ministries and private practice. Addressing current challenges of psychology, it also reviews developments in novel areas such as security, sport, and art psychology, as well as psychology of negotiations, cyberspace and virtual reality. The journal builds upon theoretical foundations laid by the works of Vygotsky, Luria and other Russian scientists whose works contributed to shaping the psychological science worldwide, and welcomes international submissions which make major contributions across the range of psychology, especially appreciating the ones conducted in the paradigm of the Russian psychological tradition. It enjoys a wide international readership and features reports of empirical studies, book reviews and theoretical contributions, which aim to further our understanding of psychology.
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