含叶磷脂体的蛇舌草提取物的开发和评价:用于治疗啮齿动物神经性疼痛模型的临床前方法。

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2023-05-01 DOI:10.1080/02652048.2023.2188938

Nitin Kumar, Radha Goel, Monika Singh, Neeraj Kant Sharma, Praveen Kumar Gaur, Pradeep Kumar Sharma

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引用次数: 0

摘要

目的:本研究旨在通过提高其主要化学成分荆草苷-A (HCA)的生物利用度，将荆草提取物(HCE)包埋在叶磷脂小体中，以提高其治疗神经性疼痛的疗效。方法:制备磷脂复合物(F1、F2、F3)， HCE与磷脂按不同比例反应。选择F2观察其对部分坐骨神经结扎所致神经性疼痛的治疗效果。对F2的伤害阈值和口服生物利用度也进行了估计。结果:F2的粒径为298.1±1.1 nm, zeta电位为-3.92±0.41 mV，包封效率为72.12±0.72%。F2提高了HCA的相对生物利用度(158.92%)，同时具有更大的神经保护潜力，显示出显著的抗氧化作用和增强作用(p)结论:F2是一种乐观的配方，可以增强HCE的传递，有效治疗神经性疼痛。

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Development and evaluation of Hedyotis corymbosa (L.) extract containing phytosomes: a preclinical approach for treatment of neuropathic pain in rodent model.

Purpose: The study was aimed to encapsulate Hedyotis corymbosa extract (HCE) into phytosomes to improve its therapeutic efficacy in neuropathic pain by enhancing the bioavailability of chief chemical constituent Hedycoryside -A (HCA).

Methods: For preparing phytosomes complexes (F1, F2, and F3), HCE and phospholipids were reacted in disparate ratio. F2 was chosen to assess its therapeutic efficacy in neuropathic pain induced by partial sciatic nerve ligation. Nociceptive threshold and oral bioavailability were also estimated for F2.

Results: Particle size, zeta potential and entrapment efficiency for F2 were analysed as 298.1 ± 1.1 nm, -3.92 ± 0.41 mV and 72.12 ± 0.72% respectively. F2 gave enhanced relative bioavailability (158.92%) of HCA along with a greater neuroprotective potential showing a significant antioxidant effect and augmentation (p < 0.05) in nociceptive threshold with the diminution in damage to nerves.

Conclusion: F2 is an optimistic formulation for enhancing the HCE delivery for the effective treatment of neuropathic pain.

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.