Flávia Gomes Matos, Anna Clara Abreu Stremel, Leandro Cavalcante Lipinski, Joni Augusto Cirelli, Fábio André Dos Santos
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Preferred Reporting for Systematic Reviews and Meta-Analyses (PRISMA) was used as a guideline; electronic searches were performed in PubMed, Scopus, Scielo, Web of Science, Embase, Science Direct, Brazilian Bibliography of Dentistry, Latin American and Caribbean Literature in Health Sciences, Directory of Open Access Journals, Database of Abstracts of Reviews of Effects, and gray literature until January 2022 (PROSPERO/CRD42021270119). Sixty-eight articles were chosen from the 2439 results. Most studies were conducted in pigs, mainly the Göttinger and Domesticus breeds. Healthy animals with implants installed in the jaws were predominant among the pig studies. Of the studies evaluating the effect of systemic diseases on osseointegration, 42% were performed in osteoporotic sheep, 32% in diabetic sheep, and 26% in diabetic pigs. Osteoporosis was primarily induced by bilateral ovariectomy and mainly assessed by X-ray densitometry. 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引用次数: 0
摘要
本系统综述旨在确定和讨论临床前研究中最常用的方法,以评估在系统受损的猪和绵羊中实施牙科植入物的情况。这项研究为未来的研究以及防止不必要的动物浪费和牺牲提供了支持和指导。系统评价和荟萃分析的首选报告(PRISMA)被用作指南;截至2022年1月,在PubMed、Scopus、Scielo、Web of Science、Embase、Science Direct、巴西牙科书目、拉丁美洲和加勒比健康科学文献、开放获取期刊目录、效果评论摘要数据库和灰色文献中进行了电子搜索(PROSPERO/CDR42021270119)。从2439篇文章中选出68篇。大多数研究都是在猪身上进行的,主要是哥廷格和Domesticus品种。在猪的研究中,颌骨植入物的健康动物占主导地位。在评估系统性疾病对骨整合影响的研究中,42%在骨质疏松的绵羊中进行,32%在糖尿病绵羊中,26%在糖尿病猪中进行。骨质疏松症主要由双侧卵巢切除术引起,主要通过X射线密度测定进行评估。糖尿病主要由静脉注射链脲佐菌素引起,并通过血糖分析得到证实。组织学和组织形态计量学分析是评估骨整合最常用的方法。在系统性疾病背景下评估牙科植入物的研究中,动物模型为每个物种提供了独特的方法。了解最常用的技术将有助于植入式研究的方法选择和未来的表现。
Dental implants in large animal models with experimental systemic diseases: A systematic review.
This systematic review aims to identify and discuss the most used methodologies in pre-clinical studies for the evaluation of the implementation of dental implants in systemically compromised pigs and sheep. This study provides support and guidance for future research, as well as for the prevention of unnecessary animal wastage and sacrifice. Preferred Reporting for Systematic Reviews and Meta-Analyses (PRISMA) was used as a guideline; electronic searches were performed in PubMed, Scopus, Scielo, Web of Science, Embase, Science Direct, Brazilian Bibliography of Dentistry, Latin American and Caribbean Literature in Health Sciences, Directory of Open Access Journals, Database of Abstracts of Reviews of Effects, and gray literature until January 2022 (PROSPERO/CRD42021270119). Sixty-eight articles were chosen from the 2439 results. Most studies were conducted in pigs, mainly the Göttinger and Domesticus breeds. Healthy animals with implants installed in the jaws were predominant among the pig studies. Of the studies evaluating the effect of systemic diseases on osseointegration, 42% were performed in osteoporotic sheep, 32% in diabetic sheep, and 26% in diabetic pigs. Osteoporosis was primarily induced by bilateral ovariectomy and mainly assessed by X-ray densitometry. Diabetes was induced predominantly by intravenous streptozotocin and was confirmed by blood glucose analysis. Histological and histomorphometric analyses were the most frequently employed in the evaluation of osseointegration. The animal models presented unique methodologies for each species in the studies that evaluated dental implants in the context of systemic diseases. Understanding the most commonly used techniques will help methodological choices and the performance of future studies in implantology.
期刊介绍:
The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.