弥漫性大b细胞淋巴瘤的程序性死亡配体1表达与不良预后相关。

IF 2.3 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Esraa Al-Khateeb, Manal A Abbas, Majd B Khader, Maher A Sughayer
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引用次数: 0

摘要

背景:程序性死亡配体1 (PD-L1)在某些肿瘤中的表达具有预后意义。本研究旨在探讨PD-L1在弥漫性大b细胞淋巴瘤(DLBCL)中的表达,并研究其与临床病理变量的关系。方法:该研究包括2015-2018年期间在侯赛因国王癌症中心接受治疗的75例DLBCL患者。采用抗人PD-L1(克隆22C3)单克隆抗体免疫组化检测肿瘤组织中PD-L1的表达。研究性别、年龄、临床分期、治疗前ldh水平、肿瘤部位、治疗反应、总生存期和无事件生存期与PD-L1表达的相关性。结果:6例患者因在组织取样时处于复发期而被排除在进一步分析之外。16/69例(23.2%)DLBCL患者肿瘤比例评分(TPS)≥1%,23/69例(33.3%)患者联合阳性评分(CPS)≥20。生发中心b细胞样(GCB)和非GCB亚型之间PD-L1表达无显著差异。同样,PD-L1表达(CPS≥20和TPS≥1)在不同性别、年龄组、临床分期、肿瘤位置和患者对治疗的反应之间也没有差异。然而,在PD-L1 CPS≥20的患者中,基线乳酸脱氢酶显著升高。pd - l1阳性组和阴性组的总生存率无显著差异。另一方面,PD-L1 TPS组或CPS阴性组的中位无事件生存期均高于PD-L1阳性组的中位无事件生存期,分别为107个月和54个月。结论:PD-L1表达可以预测DLBCL患者无事件生存期,因此预后较差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Programmed death-ligand 1 expression in diffuse large B-cell lymphoma is associated with poor prognosis.

Background: Programmed death-ligand 1 (PD-L1) expression in some tumors has prognostic implications. This work aims at investigating PD-L1 expression in diffuse large B-cell lymphoma (DLBCL) and to study its association with clinicopathological variables.

Methods: The study consisted of 75 DLBCL patients who were cared for at the King Hussein Cancer Center during the period 2015-2018. The expression of PD-L1 in tumor tissue was assessed by immunohistochemistry using the anti-human PD-L1 (Clone 22C3) monoclonal antibody. The correlation between gender, age, clinical stage, pre-treatment-LDH level, tumor location, response to therapy, overall and event-free survival with PD-L1 expression was studied.

Results: Six patients were excluded from further analysis as they were in relapse at the time of tissue sampling. The tumor proportion score (TPS) was ≥1% in 16/69 (23.2%) of DLBCL cases while the combined positive score (CPS) at a cut-off of ≥20 was observed in 23/69 (33.3%) cases. No significant difference in PD-L1 expression was found between germinal center B-cell-like (GCB) and non-GCB subtypes. Similarly, no differences in PD-L1 expression (at CPS ≥20 and TPS ≥1) were found between different genders, age groups, clinical stages, tumor location, and patient response to therapy. However, base-line lactate dehydrogenase was significantly elevated in patients with PD-L1 CPS ≥20. The overall survival was not significantly different between PD-L1-positive and -negative groups. On the other hand, the median event-free survival was higher in either of the PD-L1 TPS or CPS negative groups at 107months each versus 54 months in the PD-L1 positive group of either category.

Conclusions: PD-L1 expression can predict event-free survival in DLBCL cases and therefore poor prognosis.

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来源期刊
International Journal of Biological Markers
International Journal of Biological Markers 医学-生物工程与应用微生物
CiteScore
4.10
自引率
0.00%
发文量
43
期刊介绍: IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.
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