营养状况对儿童脐带血干细胞移植预后的影响。

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Zhongying Lu, Yongzhen Li, Peng Shi, Xiaoyan Gong, Yiyao Zhou, Xiaowen Qian, Xiaowen Zhai, Tian Qian
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引用次数: 1

摘要

背景和目的:营养状况对接受脐带血干细胞移植(UCBT)的儿童临床结果的影响尚未得到充分描述。我们评估了移植入院前营养不良的风险,以及住院期间体重减轻对UCBT儿童短期临床结果的影响。方法和研究设计:我们对2019年1月至2020年12月在复旦大学儿童医院接受UCBT治疗的18岁以下儿童患者进行了回顾性研究。结果:91例患者的平均年龄为1.3岁,男性78例(85.7%),女性13例(14.3%)。结论:移植过程中受者儿童体重过轻和体重减轻过度增加了住院时间和住院费用,并与GVHD的高发相关,影响移植预后和医疗资源消耗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of nutritional status on outcomes in children receiving umbilical cord blood stem cell transplantation.

Background and objectives: The impacts of nutritional status on clinical outcomes in children receiving umbilical cord blood stem cell transplantation (UCBT) are not fully described. We evaluated the risk for malnutrition before transplantation admission and influence of weight loss during hospitalization on short-term clinical outcomes in children with UCBT.

Methods and study design: We conducted a retrospective study of pediatric patients up to age 18 years who received UCBT and were treated at the Children's Hospital of Fudan University between January 2019 and December 2020.

Results: The mean age of the 91 patients was 1.3 years, with 78 (85.7%) men and 13 (14.3%) women (p<0.001). UCBT was performed mostly for primary immunodeficiency disease (PID) (83, 91.2%). The weight loss differences among children with different primary diseases were statistically significant (p=0.003). Children with a large amount of weight loss during hospitalization (n = 24) had higher risks of skin graft-versus-host disease (GVHD) (multivariate OR=5.01, 95% CI: 1.35-18.65), intestinal GVHD (multivariate OR=7.27, 95% CI: 1.74-30.45), a longer median hospital stay (p=0.004), higher antibiotic costs (p=0.008) and higher total hospitalization costs (p=0.004). Malnutrition on admission was significantly positively correlated with longer parenteral nutrition (PN) time (p=0.008). Early nutritional intervention effects on clinical outcomes need further assessment.

Conclusions: Underweight recipient child and excessive weight loss during transplantation increases the length and cost of hospital stay, and is associated with a high incidence of GVHD, which affects the prognosis of transplantation and medical resources consumption.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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