母体微嵌合在产后发育中的新兴作用

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Development Growth & Differentiation Pub Date : 2022-12-15 DOI:10.1111/dgd.12830

Alexandria Borges, Flore Castellan, Naoki Irie

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引用次数: 1

摘要

母体微嵌合(MMc)是指来自母体的少量细胞在其后代体内持续存在的现象。尽管它们在哺乳动物怀孕期间经常出现，但母体细胞的总体类型和作用，特别是在出生后，仍不清楚。通过使用转基因小鼠品系和人脐血样本，最近的研究首次表征和量化了后代中的MMc细胞类型库，确定了对胎儿免疫的跨代影响，并确定了影响其在后代中存在的可能因素。这篇综述总结了新的发现，特别是关于母体细胞类型库及其在子宫、出生后生活和出生后很长时间内的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Emergent roles of maternal microchimerism in postnatal development

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Emergent roles of maternal microchimerism in postnatal development

Maternal microchimerism (MMc) is the phenomenon that a low number of cells from the mother persists within her progeny. Despite their regular presence in mammalian pregnancies, the overall cell type repertoire and roles of maternal cells, especially after birth, remain unclear. By using transgenic mouse strains and human umbilical blood samples, recent studies have for the first time characterized and quantified MMc cell type repertoires in offspring, identified the cross-generational influence on fetal immunity, and determined possible factors that affect their presence in offspring. This review summarizes new findings, especially on the maternal cell type repertoires and their potential role in utero, in postnatal life, and long after birth.

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来源期刊

Development Growth & Differentiation 生物-发育生物学

CiteScore

4.60

自引率

4.00%

发文量

审稿时长

6 months

期刊介绍： Development Growth & Differentiation (DGD) publishes three types of articles: original, resource, and review papers. Original papers are on any subjects having a context in development, growth, and differentiation processes in animals, plants, and microorganisms, dealing with molecular, genetic, cellular and organismal phenomena including metamorphosis and regeneration, while using experimental, theoretical, and bioinformatic approaches. Papers on other related fields are also welcome, such as stem cell biology, genomics, neuroscience, Evodevo, Ecodevo, and medical science as well as related methodology (new or revised techniques) and bioresources. Resource papers describe a dataset, such as whole genome sequences and expressed sequence tags (ESTs), with some biological insights, which should be valuable for studying the subjects as mentioned above. Submission of review papers is also encouraged, especially those providing a new scope based on the authors’ own study, or a summarization of their study series.