柑桔皮纳米胶囊精油的制备及其体外生物学性能评价

IF 1.8 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Maryam Torshabi, Zahra MoadabShoar, Maryam Negahban
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引用次数: 2

摘要

龋齿是最常见的生物膜依赖性口腔疾病。变形链球菌是导致龋齿的主要微生物之一。制备了浓度为0.5% (v/v)的柑桔皮精油纳米悬浮液,考察了其对浮游和生物膜形式的变形链球菌的抑菌作用、细胞毒和抗氧化作用,并与氯己定(CHX)进行了比较。游离精油、纳米包封精油和CHX的最小抑菌浓度(MIC)分别为5.6% (v/v)、0.0005% (v/v)和0.0002% (w/v)。在半mic下,游离精油、纳米胶囊精油和CHX对生物膜的抑制率分别为67.3%、24%和90.6%。纳米胶囊精油在不同浓度下均无细胞毒性,且具有显著的抗氧化作用。纳米包封后的陈皮精油在较低浓度(稀释11000倍)下的生物活性显著增强。与CHX相比,它还显示出较低的细胞毒性和较高的抗生物膜作用,这表明橘子纳米胶囊精油在有机抗菌和抗氧化漱口水中的最佳应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation of Citrus reticulata peel nano-encapsulated essential oil and in vitro assessment of its biological properties

Dental caries is the most common biofilm-dependent oral disease. Streptococcus mutans is among the main microorganisms responsible for the development of dental caries. Nano-suspension of Citrus reticulata (tangerine) peel essential oil in 0.5% (v/v) concentration was prepared and its antibacterial effect on S. mutans in planktonic and biofilm forms as well as its cytotoxic and antioxidant effects were assessed and compared with chlorhexidine (CHX). The minimum inhibitory concentration (MIC) of free essential oil, nano-encapsulated essential oil, and CHX was 5.6% (v/v), 0.0005% (v/v), and 0.0002% (w/v), respectively. The percentage of biofilm inhibition by the free essential oil, nano-encapsulated essential oil, and CHX at half-MIC was 67.3%, 24%, and 90.6%, respectively. The nano-encapsulated essential oil had no cytotoxicity and showed significant antioxidant effects in different concentrations. Nano-encapsulation of tangerine peel essential oil significantly enhanced its biological activities in much lower concentrations than the free essential oil (11,000 times diluted). It also showed lower cytotoxicity and higher antibiofilm effects in sub-MICs compared with CHX, indicating the optimal potential of tangerine nano-encapsulated essential oil for incorporation in the composition of organic antibacterial and antioxidant mouth rinses.

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来源期刊
European Journal of Oral Sciences
European Journal of Oral Sciences 医学-牙科与口腔外科
CiteScore
3.50
自引率
5.30%
发文量
61
审稿时长
2 months
期刊介绍: The European Journal of Oral Sciences is an international journal which publishes original research papers within clinical dentistry, on all basic science aspects of structure, chemistry, developmental biology, physiology and pathology of relevant tissues, as well as on microbiology, biomaterials and the behavioural sciences as they relate to dentistry. In general, analytical studies are preferred to descriptive ones. Reviews, Short Communications and Letters to the Editor will also be considered for publication. The journal is published bimonthly.
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