{"title":"月桂对大鼠降压作用的研究。","authors":"Ismail Bouadid, Ayoub Amssayef, Mohamed Eddouks","doi":"10.2174/1871525720666220512154041","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>The study aimed to study the antihypertensive activity of Laurus nobilis.</p><p><strong>Background: </strong>Laurus nobilis L. is used to treat hypertension in Morocco.</p><p><strong>Objective: </strong>The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.</p><p><strong>Materials and methods: </strong>The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.</p><p><strong>Results: </strong>A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.</p><p><strong>Conclusion: </strong>The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.</p>","PeriodicalId":9535,"journal":{"name":"Cardiovascular and Hematological Agents in Medicinal Chemistry","volume":"21 1","pages":"42-54"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Study of the Antihypertensive Effect of Laurus nobilis in Rats.\",\"authors\":\"Ismail Bouadid, Ayoub Amssayef, Mohamed Eddouks\",\"doi\":\"10.2174/1871525720666220512154041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>The study aimed to study the antihypertensive activity of Laurus nobilis.</p><p><strong>Background: </strong>Laurus nobilis L. is used to treat hypertension in Morocco.</p><p><strong>Objective: </strong>The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.</p><p><strong>Materials and methods: </strong>The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.</p><p><strong>Results: </strong>A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.</p><p><strong>Conclusion: </strong>The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.</p>\",\"PeriodicalId\":9535,\"journal\":{\"name\":\"Cardiovascular and Hematological Agents in Medicinal Chemistry\",\"volume\":\"21 1\",\"pages\":\"42-54\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiovascular and Hematological Agents in Medicinal Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1871525720666220512154041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular and Hematological Agents in Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871525720666220512154041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Study of the Antihypertensive Effect of Laurus nobilis in Rats.
Aims: The study aimed to study the antihypertensive activity of Laurus nobilis.
Background: Laurus nobilis L. is used to treat hypertension in Morocco.
Objective: The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.
Materials and methods: The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.
Results: A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.
Conclusion: The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.
期刊介绍：
Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.
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