骨细胞能量学在健康和疾病中改变骨质量和强度的作用。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Carolyn Chlebek, Clifford J Rosen
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引用次数: 0

摘要

综述目的:骨质量和强度随年龄和疾病而下降,但可通过临床干预改善。能量通路对细胞功能和驱动骨细胞内的成骨信号是必不可少的。在饮食或治疗干预后,骨质量的改变与骨细胞能量活动的变化有关。能量通路可能直接或间接地促进骨质量的改变。这篇综述的目的是强调骨骼健康和疾病的组织水平和生物能量变化。骨细胞能量学是一个新兴的研究领域。早期文献主要集中于定义骨细胞在整个生命周期中的能量激活。最近的研究已经开始将骨骼能量活动与健康和疾病联系起来。在这篇综述中,我们重点介绍了骨细胞的能量需求,底物可用性对骨质量的影响,与疾病治疗和发展相关的生物能量的改变,以及影响骨细胞能量的其他生物因素。骨细胞在分化和成熟过程中使用几种能量通路。生物能量通路的协调是健康细胞功能的关键。底物可用性的系统性改变改变了骨质量,可能是由于骨细胞生物能量活性改变的直接影响。骨细胞生物能量学也可能直接有助于骨骼疾病的发展和治疗。了解能量途径在细胞对疾病反应中的作用将改善患者的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease.

Purpose of review: Bone quality and strength are diminished with age and disease but can be improved by clinical intervention. Energetic pathways are essential for cellular function and drive osteogenic signaling within bone cells. Altered bone quality is associated with changes in the energetic activity of bone cells following diet-based or therapeutic interventions. Energetic pathways may directly or indirectly contribute to changes in bone quality. The goal of this review is to highlight tissue-level and bioenergetic changes in bone health and disease.

Recent findings: Bone cell energetics are an expanding field of research. Early literature primarily focused on defining energetic activation throughout the lifespan of bone cells. Recent studies have begun to connect bone energetic activity to health and disease. In this review, we highlight bone cell energetic demands, the effect of substrate availability on bone quality, altered bioenergetics associated with disease treatment and development, and additional biological factors influencing bone cell energetics. Bone cells use several energetic pathways during differentiation and maturity. The orchestration of bioenergetic pathways is critical for healthy cell function. Systemic changes in substrate availability alter bone quality, potentially due to the direct effects of altered bone cell bioenergetic activity. Bone cell bioenergetics may also contribute directly to the development and treatment of skeletal diseases. Understanding the role of energetic pathways in the cellular response to disease will improve patient treatment.

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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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