大鼠肋软骨骨再生的影像学和组织化学研究。

IF 1.9 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Miho Higeuchi, Shunsuke Namaki, Akihiko Furukawa, Yoshiyuki Yonehara
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引用次数: 0

摘要

目的:本研究的目的是对利用软骨组织进行硬组织重建的可能性进行基础研究,并观察软骨向骨过渡过程中的形态学变化。方法:在大鼠右下颌角处制造直径为4mm的骨缺损。软骨、自体骨和人工骨移植于缺损处。计算机断层扫描(CT)测量骨体积的增加。对移植部位进行进一步的组织学评估。结果:12周时,CT显示肋软骨组骨形成与自体骨组相当。组织学上,人工骨组现有骨与缺损边界清晰,肋软骨组和自体骨组缺损可见层板骨修复。结论:本研究结果表明,软骨移植骨重建与自体骨移植几乎相当,软骨骨重建在临床上是可行的。未来,如果再生软骨在临床上应用成功,使用再生软骨进行骨重建可能是可行的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Radiological and histochemical study of bone regeneration using the costal cartilage in rats.

Purpose: The purpose of this study was to conduct basic research on the possibility of using cartilage tissue for hard-tissue reconstruction and to observe morphological changes in the transition of the cartilage to bone.

Methods: A 4-mm diameter bone defect was created in the right mandibular angle of rats. Cartilage, autologous bone, and artificial bone were grafted into the defect. Computed tomography (CT) was performed to measure the increase in bone volume. Further histological evaluation of the grafted site was performed.

Results: At 12 weeks, CT show that bone formation in the costal cartilage group was comparable to that in the autogenous bone group. Histologically, in the artificial bone group, a clear boundary was observed between the existing bone and defect, whereas in the costal cartilage and autologous bone groups, laminar plate bone repair of the defect was observed.

Conclusion: The findings in this study suggest that bone reconstruction achieved with cartilage grafting is almost equivalent to that with autogenous bone grafting and that bone reconstruction using cartilage is clinically feasible. In future, if regenerated cartilage is successfully applied clinically, bone reconstruction using regenerated cartilage may be feasible.

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来源期刊
Journal of oral science
Journal of oral science DENTISTRY, ORAL SURGERY & MEDICINE-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
3.80
自引率
0.00%
发文量
58
期刊介绍: Information not localized
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