ipsc衍生的气道上皮细胞:进展、前景和挑战。

IF 4 2区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

STEM CELLS Pub Date : 2023-01-30 DOI:10.1093/stmcls/sxac074

Fenggang Yu, Fei Liu, Xiaohua Liang, Linwei Duan, Qiongqiong Li, Ge Pan, Chengyao Ma, Minmin Liu, Mingyue Li, Peng Wang, Xuening Zhao

{"title":"ipsc衍生的气道上皮细胞:进展、前景和挑战。","authors":"Fenggang Yu, Fei Liu, Xiaohua Liang, Linwei Duan, Qiongqiong Li, Ge Pan, Chengyao Ma, Minmin Liu, Mingyue Li, Peng Wang, Xuening Zhao","doi":"10.1093/stmcls/sxac074","DOIUrl":null,"url":null,"abstract":"Induced pluripotent stem cells (iPSCs) generated from somatic cell sources are pluripotent and capable of indefinite expansion in vitro. They provide an unlimited source of cells that can be differentiated into lung progenitor cells for potential clinical use in pulmonary regenerative medicine. This review gives a comprehensive overview of recent progress toward the use of iPSCs to generate proximal and distal airway epithelial cells and mix lung organoids. Furthermore, their potential applications and future challenges for the field are discussed, with a focus on the technological hurdles that must be cleared before stem cell therapeutics can be used for clinical treatment.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":"41 1","pages":"1-10"},"PeriodicalIF":4.0000,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"iPSC-Derived Airway Epithelial Cells: Progress, Promise, and Challenges.\",\"authors\":\"Fenggang Yu, Fei Liu, Xiaohua Liang, Linwei Duan, Qiongqiong Li, Ge Pan, Chengyao Ma, Minmin Liu, Mingyue Li, Peng Wang, Xuening Zhao\",\"doi\":\"10.1093/stmcls/sxac074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Induced pluripotent stem cells (iPSCs) generated from somatic cell sources are pluripotent and capable of indefinite expansion in vitro. They provide an unlimited source of cells that can be differentiated into lung progenitor cells for potential clinical use in pulmonary regenerative medicine. This review gives a comprehensive overview of recent progress toward the use of iPSCs to generate proximal and distal airway epithelial cells and mix lung organoids. Furthermore, their potential applications and future challenges for the field are discussed, with a focus on the technological hurdles that must be cleared before stem cell therapeutics can be used for clinical treatment.\",\"PeriodicalId\":231,\"journal\":{\"name\":\"STEM CELLS\",\"volume\":\"41 1\",\"pages\":\"1-10\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2023-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"STEM CELLS\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/stmcls/sxac074\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"STEM CELLS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/stmcls/sxac074","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 5

摘要

诱导多能干细胞(iPSCs)是由体细胞来源产生的多能干细胞，能够在体外无限扩增。它们提供了无限的细胞来源，可以分化成肺祖细胞，用于肺再生医学的潜在临床应用。本文综述了利用iPSCs生成近端和远端气道上皮细胞和混合肺类器官的最新进展。此外，还讨论了它们的潜在应用和该领域未来的挑战，重点是在干细胞疗法用于临床治疗之前必须清除的技术障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

iPSC-Derived Airway Epithelial Cells: Progress, Promise, and Challenges.

Induced pluripotent stem cells (iPSCs) generated from somatic cell sources are pluripotent and capable of indefinite expansion in vitro. They provide an unlimited source of cells that can be differentiated into lung progenitor cells for potential clinical use in pulmonary regenerative medicine. This review gives a comprehensive overview of recent progress toward the use of iPSCs to generate proximal and distal airway epithelial cells and mix lung organoids. Furthermore, their potential applications and future challenges for the field are discussed, with a focus on the technological hurdles that must be cleared before stem cell therapeutics can be used for clinical treatment.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

STEM CELLS 医学-生物工程与应用微生物

CiteScore

10.30

自引率

1.90%

发文量

104

审稿时长

3 months

期刊介绍： STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. STEM CELLS covers: Cancer Stem Cells, Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells, Regenerative Medicine, Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics, Tissue-Specific Stem Cells, Translational and Clinical Research.