Hazem El-Akabawy , Mohamed Shafee , Amin Mohamed Roshdy , Ahmed Abd Al Salam
{"title":"尿中性粒细胞明胶酶相关脂钙蛋白作为肝移植后受体急性肾损伤的早期标志物","authors":"Hazem El-Akabawy , Mohamed Shafee , Amin Mohamed Roshdy , Ahmed Abd Al Salam","doi":"10.1016/j.ejccm.2016.11.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Urinary NGAL is a novel biomarker that is rapidly released after AKI.</p></div><div><h3>Purpose</h3><p>To study the value of urinary NGAL/creatinine ratio in predicting AKI in the recipient of LDLT.</p></div><div><h3>Methods</h3><p>A total of 30 recipients of LDLT were included in a prospective, randomized, two center study. All patients were subjected to a measurement of urinary NGAL/creatinine ratio and the serum creatinine at fashioned time intervals to assess which can predict early renal impairment; accordingly, these data were applied on mortality and hospital stay.</p></div><div><h3>Results</h3><p>Urinary NGAL/creatinine ratio was significant in detecting renal impairment as early as 3, 18, and 24<!--> <!-->h post induction of anesthesia (p<!--> <!-->=<!--> <!-->0.001 for all), while it was not significant preoperatively (p<!--> <!-->=<!--> <!-->0.817). Serum creatinine was not significant during the 1st and 2nd days (p<!--> <!-->=<!--> <!-->0.748 and 0.157 respectively), but began to be significant during the 3rd and 4th days (p<!--> <!--><<!--> <!-->0.001 for both). Urinary NGAL/creatinine ratio was correlated with ICU stay (r<!--> <!-->=<!--> <!-->0.758 with p<!--> <!--><<!--> <!-->0.001) and mortality during 3, 18, and 24<!--> <!-->h postoperative (p<!--> <!--><<!--> <!-->0.001, <0.001 and 0.005 respectively). The most sensitive in detecting mortality was urinary NGAL/creatinine ratio after 3<!--> <!-->h of the operation with a sensitivity of 100% and a specificity of 95.5%.</p></div><div><h3>Conclusion</h3><p>Urinary NGAL/creatinine ratio may be used as a test for the early prediction of adverse outcome of LDLT recipient patients at ICU admission.</p></div>","PeriodicalId":31233,"journal":{"name":"Egyptian Journal of Critical Care Medicine","volume":"5 1","pages":"Pages 49-55"},"PeriodicalIF":0.3000,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ejccm.2016.11.001","citationCount":"1","resultStr":"{\"title\":\"Urinary neutrophil gelatinase associated lipocalin as an early marker of acute kidney injury in the recipient after liver transplantation\",\"authors\":\"Hazem El-Akabawy , Mohamed Shafee , Amin Mohamed Roshdy , Ahmed Abd Al Salam\",\"doi\":\"10.1016/j.ejccm.2016.11.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Urinary NGAL is a novel biomarker that is rapidly released after AKI.</p></div><div><h3>Purpose</h3><p>To study the value of urinary NGAL/creatinine ratio in predicting AKI in the recipient of LDLT.</p></div><div><h3>Methods</h3><p>A total of 30 recipients of LDLT were included in a prospective, randomized, two center study. All patients were subjected to a measurement of urinary NGAL/creatinine ratio and the serum creatinine at fashioned time intervals to assess which can predict early renal impairment; accordingly, these data were applied on mortality and hospital stay.</p></div><div><h3>Results</h3><p>Urinary NGAL/creatinine ratio was significant in detecting renal impairment as early as 3, 18, and 24<!--> <!-->h post induction of anesthesia (p<!--> <!-->=<!--> <!-->0.001 for all), while it was not significant preoperatively (p<!--> <!-->=<!--> <!-->0.817). Serum creatinine was not significant during the 1st and 2nd days (p<!--> <!-->=<!--> <!-->0.748 and 0.157 respectively), but began to be significant during the 3rd and 4th days (p<!--> <!--><<!--> <!-->0.001 for both). Urinary NGAL/creatinine ratio was correlated with ICU stay (r<!--> <!-->=<!--> <!-->0.758 with p<!--> <!--><<!--> <!-->0.001) and mortality during 3, 18, and 24<!--> <!-->h postoperative (p<!--> <!--><<!--> <!-->0.001, <0.001 and 0.005 respectively). The most sensitive in detecting mortality was urinary NGAL/creatinine ratio after 3<!--> <!-->h of the operation with a sensitivity of 100% and a specificity of 95.5%.</p></div><div><h3>Conclusion</h3><p>Urinary NGAL/creatinine ratio may be used as a test for the early prediction of adverse outcome of LDLT recipient patients at ICU admission.</p></div>\",\"PeriodicalId\":31233,\"journal\":{\"name\":\"Egyptian Journal of Critical Care Medicine\",\"volume\":\"5 1\",\"pages\":\"Pages 49-55\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2017-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ejccm.2016.11.001\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Critical Care Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2090730316300688\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CRITICAL CARE MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Critical Care Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2090730316300688","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}
Urinary neutrophil gelatinase associated lipocalin as an early marker of acute kidney injury in the recipient after liver transplantation
Background
Urinary NGAL is a novel biomarker that is rapidly released after AKI.
Purpose
To study the value of urinary NGAL/creatinine ratio in predicting AKI in the recipient of LDLT.
Methods
A total of 30 recipients of LDLT were included in a prospective, randomized, two center study. All patients were subjected to a measurement of urinary NGAL/creatinine ratio and the serum creatinine at fashioned time intervals to assess which can predict early renal impairment; accordingly, these data were applied on mortality and hospital stay.
Results
Urinary NGAL/creatinine ratio was significant in detecting renal impairment as early as 3, 18, and 24 h post induction of anesthesia (p = 0.001 for all), while it was not significant preoperatively (p = 0.817). Serum creatinine was not significant during the 1st and 2nd days (p = 0.748 and 0.157 respectively), but began to be significant during the 3rd and 4th days (p < 0.001 for both). Urinary NGAL/creatinine ratio was correlated with ICU stay (r = 0.758 with p < 0.001) and mortality during 3, 18, and 24 h postoperative (p < 0.001, <0.001 and 0.005 respectively). The most sensitive in detecting mortality was urinary NGAL/creatinine ratio after 3 h of the operation with a sensitivity of 100% and a specificity of 95.5%.
Conclusion
Urinary NGAL/creatinine ratio may be used as a test for the early prediction of adverse outcome of LDLT recipient patients at ICU admission.
期刊介绍：
The Egyptian Journal of Critical Care Medicine is the official Journal of the Egyptian College of Critical Care Physicians, the most authoritative organization of Egyptian physicians involved in the multi-professional field of critical care medicine. The journal is intended to provide a peer-reviewed source for multidisciplinary coverage of general acute and intensive care medicine and its various subcategories including cardiac, pulmonary, neuro, renal as well as post-operative care. The journal is proud to have an international multi-professional editorial board in the broad field of critical care that will assist in publishing promising research and breakthrough reports that lead to better patients care in life threatening conditions, and bring the reader a quick access to the latest diagnostic and therapeutic approaches in monitoring and management of critically ill patients.
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