Drp1-Fis1通路介导的线粒体分裂与神经退行性疾病。

IF 3.4 3区医学 Q2 NEUROSCIENCES

Reviews in the Neurosciences Pub Date : 2023-04-25 DOI:10.1515/revneuro-2022-0056

Wenjia Shi, Cheng Tan, Can Liu, Dan Chen

{"title":"Drp1-Fis1通路介导的线粒体分裂与神经退行性疾病。","authors":"Wenjia Shi, Cheng Tan, Can Liu, Dan Chen","doi":"10.1515/revneuro-2022-0056","DOIUrl":null,"url":null,"abstract":"In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 3","pages":"275-294"},"PeriodicalIF":3.4000,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":"{\"title\":\"Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases.\",\"authors\":\"Wenjia Shi, Cheng Tan, Can Liu, Dan Chen\",\"doi\":\"10.1515/revneuro-2022-0056\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.\",\"PeriodicalId\":49623,\"journal\":{\"name\":\"Reviews in the Neurosciences\",\"volume\":\"34 3\",\"pages\":\"275-294\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2023-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reviews in the Neurosciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1515/revneuro-2022-0056\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews in the Neurosciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/revneuro-2022-0056","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 9

摘要

近年来，线粒体动力学在神经退行性疾病中的作用越来越重要。越来越多的证据表明，在病理条件下，线粒体异常分裂，特别是drp1 - fis1介导的分裂，在阿尔茨海默病、帕金森病、肌萎缩性侧索硬化症、亨廷顿病、青光眼等神经退行性疾病的发生发展中起着重要作用。本文综述了线粒体生理性分裂的几种新的机制以及生理性和病理性线粒体分裂的区别/联系。此外，我们详细描述了线粒体异常动力学与神经退行性疾病的关系，并在基础实验中重点总结了其检测指标，试图为进一步的机制探索和治疗靶点提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases.

In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Reviews in the Neurosciences 医学-神经科学

CiteScore

9.40

自引率

2.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Reviews in the Neurosciences provides a forum for reviews, critical evaluations and theoretical treatment of selective topics in the neurosciences. The journal is meant to provide an authoritative reference work for those interested in the structure and functions of the nervous system at all levels of analysis, including the genetic, molecular, cellular, behavioral, cognitive and clinical neurosciences. Contributions should contain a critical appraisal of specific areas and not simply a compilation of published articles.