{"title":"癌症患者的念珠菌血流感染:11年的回顾性分析","authors":"Rodrigo Vázquez-Olvera , Patricia Volkow , Consuelo Velázquez-Acosta , Patricia Cornejo-Juárez","doi":"10.1016/j.riam.2022.12.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><em>Candida</em> bloodstream infection (CBSI) is a growing problem among patients with cancer.</p></div><div><h3>Aim</h3><p>To describe the main clinical and microbiological characteristics in patients with cancer who suffer CBSI.</p></div><div><h3>Methods</h3><p>We reviewed the clinical and microbiological characteristics of all patients with CBSI diagnosed between January 2010 and December 2020, at a tertiary-care oncological hospital. Analysis was done according to the <em>Candida</em> species found. Multivariate logistic regression analysis was used to determine the risk factors associated with 30-day mortality.</p></div><div><h3>Results</h3><p>There were 147 CBSIs diagnosed, 78 (53%) in patients with hematologic malignancies. The main <em>Candida</em> species identified were <span><em>Candida albicans</em></span> (<em>n</em> <!-->=<!--> <!-->54), <span><em>Candida glabrata</em></span> (<em>n</em> <!-->=<!--> <!-->40) and <span><em>Candida tropicalis</em></span> (<em>n</em> <!-->=<!--> <!-->29). <em>C. tropicalis</em> had been mainly isolated from patients with hematologic malignancies (79.3%) who had received chemotherapy recently (82.8%), and in patients with severe neutropenia (79.3%). Seventy-five (51%) patients died within the first 30 days, and the multivariate analysis showed the following risk factors: severe neutropenia, a Karnofsky Performance Scale score under 70, septic shock, and not receiving appropriate antifungal treatment.</p></div><div><h3>Conclusions</h3><p>Patients with cancer who develop CBSI had a high mortality related with factors associated with their malignancy. Starting an empirical antifungal therapy the soonest is essential to increase the survival in these patients.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":"40 1","pages":"Pages 3-9"},"PeriodicalIF":1.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Candida bloodstream infection in patients with cancer: A retrospective analysis of an 11-year period\",\"authors\":\"Rodrigo Vázquez-Olvera , Patricia Volkow , Consuelo Velázquez-Acosta , Patricia Cornejo-Juárez\",\"doi\":\"10.1016/j.riam.2022.12.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><em>Candida</em> bloodstream infection (CBSI) is a growing problem among patients with cancer.</p></div><div><h3>Aim</h3><p>To describe the main clinical and microbiological characteristics in patients with cancer who suffer CBSI.</p></div><div><h3>Methods</h3><p>We reviewed the clinical and microbiological characteristics of all patients with CBSI diagnosed between January 2010 and December 2020, at a tertiary-care oncological hospital. Analysis was done according to the <em>Candida</em> species found. Multivariate logistic regression analysis was used to determine the risk factors associated with 30-day mortality.</p></div><div><h3>Results</h3><p>There were 147 CBSIs diagnosed, 78 (53%) in patients with hematologic malignancies. The main <em>Candida</em> species identified were <span><em>Candida albicans</em></span> (<em>n</em> <!-->=<!--> <!-->54), <span><em>Candida glabrata</em></span> (<em>n</em> <!-->=<!--> <!-->40) and <span><em>Candida tropicalis</em></span> (<em>n</em> <!-->=<!--> <!-->29). <em>C. tropicalis</em> had been mainly isolated from patients with hematologic malignancies (79.3%) who had received chemotherapy recently (82.8%), and in patients with severe neutropenia (79.3%). Seventy-five (51%) patients died within the first 30 days, and the multivariate analysis showed the following risk factors: severe neutropenia, a Karnofsky Performance Scale score under 70, septic shock, and not receiving appropriate antifungal treatment.</p></div><div><h3>Conclusions</h3><p>Patients with cancer who develop CBSI had a high mortality related with factors associated with their malignancy. Starting an empirical antifungal therapy the soonest is essential to increase the survival in these patients.</p></div>\",\"PeriodicalId\":21291,\"journal\":{\"name\":\"Revista Iberoamericana De Micologia\",\"volume\":\"40 1\",\"pages\":\"Pages 3-9\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Iberoamericana De Micologia\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1130140623000025\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MYCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Iberoamericana De Micologia","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1130140623000025","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}
Candida bloodstream infection in patients with cancer: A retrospective analysis of an 11-year period
Background
Candida bloodstream infection (CBSI) is a growing problem among patients with cancer.
Aim
To describe the main clinical and microbiological characteristics in patients with cancer who suffer CBSI.
Methods
We reviewed the clinical and microbiological characteristics of all patients with CBSI diagnosed between January 2010 and December 2020, at a tertiary-care oncological hospital. Analysis was done according to the Candida species found. Multivariate logistic regression analysis was used to determine the risk factors associated with 30-day mortality.
Results
There were 147 CBSIs diagnosed, 78 (53%) in patients with hematologic malignancies. The main Candida species identified were Candida albicans (n = 54), Candida glabrata (n = 40) and Candida tropicalis (n = 29). C. tropicalis had been mainly isolated from patients with hematologic malignancies (79.3%) who had received chemotherapy recently (82.8%), and in patients with severe neutropenia (79.3%). Seventy-five (51%) patients died within the first 30 days, and the multivariate analysis showed the following risk factors: severe neutropenia, a Karnofsky Performance Scale score under 70, septic shock, and not receiving appropriate antifungal treatment.
Conclusions
Patients with cancer who develop CBSI had a high mortality related with factors associated with their malignancy. Starting an empirical antifungal therapy the soonest is essential to increase the survival in these patients.
期刊介绍：
Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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