体内体细胞重编程早期事件的路线图。

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2023-02-01 DOI:10.1089/cell.2022.0160

Diana Guallar

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引用次数: 0

摘要

小鼠胰腺在体内部分重编程时的单细胞转录组学和原位成像揭示了Oct4, Sox2, Klf4和cMyc (OSKM)诱导的转录动力学。有趣的是，在胰腺中观察到的部分重编程的转录组特征在OSKM诱导和成纤维细胞体外重编程过程中被几个组织共享，这表明存在对早期重编程、再生和返老返老至关重要的保守途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Roadmap of the Early Events of In Vivo Somatic Cell Reprogramming.

Single-cell transcriptomics and in situ imaging of murine pancreas upon partial reprogramming in vivo reveal transcriptional dynamics upon Oct4, Sox2, Klf4, and cMyc (OSKM) induction. Interestingly, transcriptomic signatures of partial reprogramming observed in pancreas are shared by several tissues upon OSKM induction as well as during in vitro reprogramming of fibroblasts, pointing to the existence of conserved pathways critical for early reprogramming, regeneration, and rejuvenation.

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.