{"title":"尘肺患者血清胆红素水平与疾病严重程度。","authors":"You-Fan Peng, Jun-Hua Deng, Xiao-Ying Huang, Qing-Song Zhang","doi":"10.1155/2023/5642040","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis.</p><p><strong>Methods: </strong>The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity.</p><p><strong>Results: </strong>Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage (<i>p</i> = 0.012) but not serum indirect bilirubin. Serum direct bilirubin was negatively correlated with radiological severity in patients with pneumoconiosis (<i>r</i> = -0.320; <i>p</i> = 0.032); by multiple linear-regression analysis, we observed that serum direct bilirubin levels had independent association with radiological severity in patients with pneumoconiosis (beta = -0.459; <i>p</i> = 0.005).</p><p><strong>Conclusions: </strong>Serum direct bilirubin levels are negatively associated with disease severity in patients with pneumoconiosis.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030211/pdf/","citationCount":"0","resultStr":"{\"title\":\"Serum Bilirubin Levels and Disease Severity in Patients with Pneumoconiosis.\",\"authors\":\"You-Fan Peng, Jun-Hua Deng, Xiao-Ying Huang, Qing-Song Zhang\",\"doi\":\"10.1155/2023/5642040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis.</p><p><strong>Methods: </strong>The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity.</p><p><strong>Results: </strong>Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage (<i>p</i> = 0.012) but not serum indirect bilirubin. Serum direct bilirubin was negatively correlated with radiological severity in patients with pneumoconiosis (<i>r</i> = -0.320; <i>p</i> = 0.032); by multiple linear-regression analysis, we observed that serum direct bilirubin levels had independent association with radiological severity in patients with pneumoconiosis (beta = -0.459; <i>p</i> = 0.005).</p><p><strong>Conclusions: </strong>Serum direct bilirubin levels are negatively associated with disease severity in patients with pneumoconiosis.</p>\",\"PeriodicalId\":9416,\"journal\":{\"name\":\"Canadian respiratory journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030211/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian respiratory journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/5642040\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian respiratory journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2023/5642040","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Serum Bilirubin Levels and Disease Severity in Patients with Pneumoconiosis.
Aim: To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis.
Methods: The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity.
Results: Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage (p = 0.012) but not serum indirect bilirubin. Serum direct bilirubin was negatively correlated with radiological severity in patients with pneumoconiosis (r = -0.320; p = 0.032); by multiple linear-regression analysis, we observed that serum direct bilirubin levels had independent association with radiological severity in patients with pneumoconiosis (beta = -0.459; p = 0.005).
Conclusions: Serum direct bilirubin levels are negatively associated with disease severity in patients with pneumoconiosis.
期刊介绍:
Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.