{"title":"miR-590的生物学功能及其在癌变中的作用","authors":"Yang Dong, Guang-Bin Qiu","doi":"10.1016/j.flm.2017.11.002","DOIUrl":null,"url":null,"abstract":"<div><p>MicroRNAs (miRNAs), a class of non-coding single small RNAs transcribed from Eukaryotic genes, regulate gene expression at post-transcriptional levels via binding to 3′-untranslation region (3′ UTR) inducing translation inhibition or mRNA degradation of their targets. MiR-590 plays a key role in cellular proliferation, differentiation, apoptosis and aging, and participates in development and progress of many diseases including cancer. Furthermore, miR-590 has different functions as a tumor suppressor or an oncogene by targeting various genes. This review is to summarize the structure, biological function and role of the miR-590 gene.</p></div>","PeriodicalId":100555,"journal":{"name":"Frontiers in Laboratory Medicine","volume":"1 4","pages":"Pages 173-176"},"PeriodicalIF":0.0000,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.flm.2017.11.002","citationCount":"9","resultStr":"{\"title\":\"Biological functions of miR-590 and its role in carcinogenesis\",\"authors\":\"Yang Dong, Guang-Bin Qiu\",\"doi\":\"10.1016/j.flm.2017.11.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>MicroRNAs (miRNAs), a class of non-coding single small RNAs transcribed from Eukaryotic genes, regulate gene expression at post-transcriptional levels via binding to 3′-untranslation region (3′ UTR) inducing translation inhibition or mRNA degradation of their targets. MiR-590 plays a key role in cellular proliferation, differentiation, apoptosis and aging, and participates in development and progress of many diseases including cancer. Furthermore, miR-590 has different functions as a tumor suppressor or an oncogene by targeting various genes. This review is to summarize the structure, biological function and role of the miR-590 gene.</p></div>\",\"PeriodicalId\":100555,\"journal\":{\"name\":\"Frontiers in Laboratory Medicine\",\"volume\":\"1 4\",\"pages\":\"Pages 173-176\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.flm.2017.11.002\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Laboratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2542364917301115\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2542364917301115","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Biological functions of miR-590 and its role in carcinogenesis
MicroRNAs (miRNAs), a class of non-coding single small RNAs transcribed from Eukaryotic genes, regulate gene expression at post-transcriptional levels via binding to 3′-untranslation region (3′ UTR) inducing translation inhibition or mRNA degradation of their targets. MiR-590 plays a key role in cellular proliferation, differentiation, apoptosis and aging, and participates in development and progress of many diseases including cancer. Furthermore, miR-590 has different functions as a tumor suppressor or an oncogene by targeting various genes. This review is to summarize the structure, biological function and role of the miR-590 gene.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
