液体活检及其在风湿病学中的新作用。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Critical Reviews in Immunology Pub Date : 2022-01-01 DOI:10.1615/CritRevImmunol.2022045288

Marta Świecka, Maria Maślińska

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引用次数: 0

摘要

液体活检是一种快速发展的诊断技术，用于分析血液或其他体液中发现的组织来源信息。它代表了一种指导治疗决策的新方法，主要是在癌症方面，但它在其他医学领域的应用仍在增长。在这里，我们讨论液体活检如何用于自身免疫性风湿性疾病，如类风湿关节炎、系统性红斑狼疮或原发性Sjögren综合征。此外，在液体活检方面，我们分析了风湿病学领域中使用的分子生物标志物，包括循环无细胞DNA, microRNA和蛋白质组学含量。

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Liquid Biopsy and Its Emerging Role in Rheumatology.

Liquid biopsy is a rapidly evolving diagnostic technique used to analyze tissue-derived information found in the blood or other bodily fluids. It represents a new way to guide therapeutic decisions, mainly in cancer, but its application in other fields of medicine is still growing. Here, we discuss how liquid biopsy has been used in autoimmune rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, or primary Sjögren's syndrome. Additionally, in aspect of liquid biopsy, we analyze the molecular biomarkers utilized in the field of rheumatology, including circulating cell-free DNA, microRNA, and proteomic content.

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来源期刊

Critical Reviews in Immunology 医学-免疫学

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Immunology covers a broad spectrum of investigations at the genes, molecular, cellular, organ and system levels to reveal defense mechanisms against pathogens as well as protection against tumors and autoimmune diseases. The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in medical sciences. Critical ReviewsTM in Immunology (CRI) seeks to present a balanced overview of contemporary adaptive and innate immune responses related to autoimmunity, tumor, microbe, transplantation, neuroimmunology, immune regulation and immunotherapy from basic to translational aspects in health and disease. The articles that appear in CRI are mostly obtained by invitations to active investigators. But the journal will also consider proposals from the scientific community. Interested investigators should send their inquiries to the editor before submitting a manuscript.