凝胶球形微颗粒在聚合物悬浮液中的制备

Zdeněk Plichta , Jiří Lenfeld , Milan J. Beneš , William H. Scouten
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引用次数: 4

摘要

明胶球形微粒是通过将20 wt%的明胶水溶液悬浮在10 wt%的聚乙烯吡咯烷酮水溶液中制备的。明胶要么未经改性,要么用水或氢氧化铵提取。在60℃下进行悬浮。当使用提取的明胶或在悬浮介质中加入氢氧化铵时,颗粒大小大大减小。随着搅拌强度的增大,颗粒尺寸减小,颗粒的稳定性也随之降低。通过冷却和甲醛交联稳定颗粒,并通过甲醇洗涤从悬浮介质中分离出来。所得颗粒用乙酸乙酯干燥。在干燥状态下,制备了5个粒径在0.5 ~ 15 μm之间的明胶微粒样品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation of gelatin spherical microparticles in aqueous polymer suspension

Gelatin spherical microparticles were prepared by suspending a 20 wt% aqueous solution of gelatin in a 10 wt% aqueous solution of polyvinylpyrrolidone. Gelatin was used either without modification, or it was extracted with water or ammonium hydroxide. Suspending was carried out at 60°C. The particle size decreased considerably when the extracted gelatin was used, or when ammonium hydroxide was added to the suspension medium. Increasing the stirring intensity decreased the particle size and also the stability of the particles. The particles were stabilized by cooling and crosslinking with formaldehyde and separated from the suspension medium by washing with methanol. The resulting particles were dried of ethyl acetate. Five samples of the gelatin microparticles were prepared, the diameters of which varied from 0.5 to 15 μm in dry state.

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