P Srinivas , P Brust , A.R Subramanian , S.A.V Raghavan , J.B Rangisetty , C.N.V.H.B Gupta , P Parimoo
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Synthesis and preliminary binding affinities of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine — a new arylpiperazine
The first synthesis of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine 5 — a new arylpiperazine is described. Preliminary binding studies on this new arylpiperazine reveal affinity for the 5-HT1A and 5-HT2A receptor subtypes. Incorporation of a dopamine pharmacophore onto this arylpiperazine provided compound 7 a potential antipsychotic with an atypical profile.
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