{"title":"全身服用他汀类药物后牙周临床状况的变化","authors":"David Rosenberg , Catherine Andrade , Ricardo Larrea , Alejandra Chaparro , Carolina Inostroza , Valeria Ramirez , Cinthya Urquidi , Deborah Violant , José Nart","doi":"10.1016/j.piro.2015.03.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To describe changes in periodontal clinical status of patients according to systemic statin use prescribed by a cardiologist.</p></div><div><h3>Material and methods</h3><p>A descriptive study was performed on patients with chronic periodontitis referred from the Department of Cardiovascular Diseases of Dávila Clinic. A group of them began statin therapy. Clinical measurements of periodontal probing depth (PD), clinical attachment level, bleeding index, periodontal inflamed surface area, and gingival index, were performed at baseline (before starting statin therapy) and 6 months later. Data were analyzed using descriptive statistics.</p></div><div><h3>Results</h3><p>A total of 10 patients participated in the study, and five of them received statin therapy. The statin group compared to the group without statins, showed a mean decrease in: PD (0.4<!--> <!-->mm versus 0.13<!--> <!-->mm); percentage of PS sites<!--> <!-->≥<!--> <!-->5<!--> <!-->mm (4.16% versus 1.09%); clinical attachment level (0.5<!--> <!-->mm versus 0.2<!--> <!-->mm), bleeding index (27.16% versus 8.8%), and periodontal inflamed surface area (305.68 versus 121.35 mm<sup>2</sup>).</p></div><div><h3>Conclusions</h3><p>These results suggest that patients with chronic periodontitis may benefit from systemic therapy with statins. Randomized clinical trials with optimal sample size are required to check the effect and impact of statins on the periodontal status.</p></div>","PeriodicalId":21203,"journal":{"name":"Revista clínica de periodoncia, implantología y rehabilitación oral","volume":"8 2","pages":"Pages 111-116"},"PeriodicalIF":0.0000,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.piro.2015.03.005","citationCount":"0","resultStr":"{\"title\":\"Cambios del estado clínico periodontal según consumo sistémico de estatinas\",\"authors\":\"David Rosenberg , Catherine Andrade , Ricardo Larrea , Alejandra Chaparro , Carolina Inostroza , Valeria Ramirez , Cinthya Urquidi , Deborah Violant , José Nart\",\"doi\":\"10.1016/j.piro.2015.03.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To describe changes in periodontal clinical status of patients according to systemic statin use prescribed by a cardiologist.</p></div><div><h3>Material and methods</h3><p>A descriptive study was performed on patients with chronic periodontitis referred from the Department of Cardiovascular Diseases of Dávila Clinic. A group of them began statin therapy. Clinical measurements of periodontal probing depth (PD), clinical attachment level, bleeding index, periodontal inflamed surface area, and gingival index, were performed at baseline (before starting statin therapy) and 6 months later. Data were analyzed using descriptive statistics.</p></div><div><h3>Results</h3><p>A total of 10 patients participated in the study, and five of them received statin therapy. The statin group compared to the group without statins, showed a mean decrease in: PD (0.4<!--> <!-->mm versus 0.13<!--> <!-->mm); percentage of PS sites<!--> <!-->≥<!--> <!-->5<!--> <!-->mm (4.16% versus 1.09%); clinical attachment level (0.5<!--> <!-->mm versus 0.2<!--> <!-->mm), bleeding index (27.16% versus 8.8%), and periodontal inflamed surface area (305.68 versus 121.35 mm<sup>2</sup>).</p></div><div><h3>Conclusions</h3><p>These results suggest that patients with chronic periodontitis may benefit from systemic therapy with statins. Randomized clinical trials with optimal sample size are required to check the effect and impact of statins on the periodontal status.</p></div>\",\"PeriodicalId\":21203,\"journal\":{\"name\":\"Revista clínica de periodoncia, implantología y rehabilitación oral\",\"volume\":\"8 2\",\"pages\":\"Pages 111-116\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.piro.2015.03.005\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista clínica de periodoncia, implantología y rehabilitación oral\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0718539115000397\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista clínica de periodoncia, implantología y rehabilitación oral","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0718539115000397","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的描述心脏病专家开具的全身他汀类药物处方对患者牙周临床状况的影响。材料与方法对Dávila诊所心血管病科转诊的慢性牙周炎患者进行描述性研究。其中一组开始接受他汀类药物治疗。在基线(开始他汀类药物治疗前)和6个月后进行牙周探诊深度(PD)、临床附着水平、出血指数、牙周炎症表面积和牙龈指数的临床测量。数据分析采用描述性统计。结果共10例患者参与研究，其中5例接受他汀类药物治疗。他汀类药物组与非他汀类药物组相比，PD平均下降(0.4 mm对0.13 mm);PS位点≥5 mm的比例(4.16% vs 1.09%);临床附着水平(0.5 mm对0.2 mm)、出血指数(27.16%对8.8%)和牙周发炎表面积(305.68对121.35 mm2)。结论慢性牙周炎患者可以接受他汀类药物的全身治疗。需要有最佳样本量的随机临床试验来检查他汀类药物对牙周状况的影响。
Cambios del estado clínico periodontal según consumo sistémico de estatinas
Objective
To describe changes in periodontal clinical status of patients according to systemic statin use prescribed by a cardiologist.
Material and methods
A descriptive study was performed on patients with chronic periodontitis referred from the Department of Cardiovascular Diseases of Dávila Clinic. A group of them began statin therapy. Clinical measurements of periodontal probing depth (PD), clinical attachment level, bleeding index, periodontal inflamed surface area, and gingival index, were performed at baseline (before starting statin therapy) and 6 months later. Data were analyzed using descriptive statistics.
Results
A total of 10 patients participated in the study, and five of them received statin therapy. The statin group compared to the group without statins, showed a mean decrease in: PD (0.4 mm versus 0.13 mm); percentage of PS sites ≥ 5 mm (4.16% versus 1.09%); clinical attachment level (0.5 mm versus 0.2 mm), bleeding index (27.16% versus 8.8%), and periodontal inflamed surface area (305.68 versus 121.35 mm2).
Conclusions
These results suggest that patients with chronic periodontitis may benefit from systemic therapy with statins. Randomized clinical trials with optimal sample size are required to check the effect and impact of statins on the periodontal status.
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